The quadrivalent HPV vaccine in Manitoba, Canada: from program implementation to real-world effectiveness
dc.contributor.author | Willows, Karla | |
dc.contributor.examiningcommittee | Kliewer, Erich (Community Health Sciences) Altman, Alon (Obstetrics, Gynecology, and Reproductive Sciences) | en_US |
dc.contributor.supervisor | Mahmud, Salaheddin (Community Health Sciences) | en_US |
dc.date.accessioned | 2017-09-14T13:42:04Z | |
dc.date.available | 2017-09-14T13:42:04Z | |
dc.date.issued | 2017 | |
dc.degree.discipline | Community Health Sciences | en_US |
dc.degree.level | Master of Science (M.Sc.) | en_US |
dc.description.abstract | This document is presented as a manuscript-style thesis. Chapter 1 provides general overview of structure and content. Chapter 2 provides a background literature search, including randomized evidence for HPV vaccination which provided the basis for immunization programs worldwide. We discuss the challenges in applying randomized evidence to the real-world setting. Chapter 3 discusses the development and rationale for the current HPV vaccination program in Manitoba, Canada. In chapter 4, we present a systematic review and meta-analysis on the efficacy and safety of a 2-dose versus 3-dose HPV vaccination schedule. In chapter 5, we present a historical matched cohort study to assess the effectiveness of the QHPV program in Manitoba in reducing the incidence of medically-attended anogenital warts. The work in chapters 4 and 5 are presented as they were submitted for consideration for peer-reviewed publication. Chapter 6 provides a summary of key findings, and discussion around policy implications. | en_US |
dc.description.note | October 2017 | en_US |
dc.identifier.uri | http://hdl.handle.net/1993/32598 | |
dc.language.iso | eng | en_US |
dc.rights | open access | en_US |
dc.subject | anogenital warts | en_US |
dc.subject | vaccine | en_US |
dc.subject | effectiveness | en_US |
dc.subject | cohort | en_US |
dc.subject | human papillomavirus | en_US |
dc.title | The quadrivalent HPV vaccine in Manitoba, Canada: from program implementation to real-world effectiveness | en_US |
dc.type | master thesis | en_US |
local.subject.manitoba | yes | en_US |
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