The quadrivalent HPV vaccine in Manitoba, Canada: from program implementation to real-world effectiveness

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dc.contributor.authorWillows, Karla
dc.contributor.examiningcommitteeKliewer, Erich (Community Health Sciences) Altman, Alon (Obstetrics, Gynecology, and Reproductive Sciences)en_US
dc.contributor.supervisorMahmud, Salaheddin (Community Health Sciences)en_US
dc.date.accessioned2017-09-14T13:42:04Z
dc.date.available2017-09-14T13:42:04Z
dc.date.issued2017
dc.degree.disciplineCommunity Health Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThis document is presented as a manuscript-style thesis. Chapter 1 provides general overview of structure and content. Chapter 2 provides a background literature search, including randomized evidence for HPV vaccination which provided the basis for immunization programs worldwide. We discuss the challenges in applying randomized evidence to the real-world setting. Chapter 3 discusses the development and rationale for the current HPV vaccination program in Manitoba, Canada. In chapter 4, we present a systematic review and meta-analysis on the efficacy and safety of a 2-dose versus 3-dose HPV vaccination schedule. In chapter 5, we present a historical matched cohort study to assess the effectiveness of the QHPV program in Manitoba in reducing the incidence of medically-attended anogenital warts. The work in chapters 4 and 5 are presented as they were submitted for consideration for peer-reviewed publication. Chapter 6 provides a summary of key findings, and discussion around policy implications.en_US
dc.description.noteOctober 2017en_US
dc.identifier.urihttp://hdl.handle.net/1993/32598
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectanogenital wartsen_US
dc.subjectvaccineen_US
dc.subjecteffectivenessen_US
dc.subjectcohorten_US
dc.subjecthuman papillomavirusen_US
dc.titleThe quadrivalent HPV vaccine in Manitoba, Canada: from program implementation to real-world effectivenessen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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