Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective

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dc.contributor.authorLaverdiere, Michel
dc.contributor.authorBow, Eric J
dc.contributor.authorRotstein, Coleman
dc.contributor.authorAutmizguine, Julie
dc.contributor.authorBroady, Raewyn
dc.contributor.authorGarber, Gary
dc.contributor.authorHaider, Shariq
dc.contributor.authorHussaini, Trana
dc.contributor.authorHusain, Shahid
dc.contributor.authorOvetchkine, Philippe
dc.contributor.authorSeki, Jack T
dc.contributor.authorThéorêt, Yves
dc.date.accessioned2016-06-07T17:38:35Z
dc.date.available2016-06-07T17:38:35Z
dc.date.issued2014-1-1
dc.date.updated2016-06-07T06:52:44Z
dc.description.abstractInvasive fungal infections cause significant morbidity and mortality in patients with concomitant underlying immunosuppressive diseases. The recent addition of new triazoles to the antifungal armamentarium has allowed for extended-spectrum activity and flexibility of administration. Over the years, clinical use has raised concerns about the degree of drug exposure following standard approved drug dosing, questioning the need for therapeutic drug monitoring (TDM). Accordingly, the present guidelines focus on TDM of triazole antifungal agents. A review of the rationale for triazole TDM, the targeted patient populations and available laboratory methods, as well as practical recommendations based on current evidence from an extended literature review are provided in the present document.
dc.description.versionPeer Reviewed
dc.identifier.citationMichel Laverdiere, Eric J Bow, Coleman Rotstein, et al., “Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective,” Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 25, no. 6, pp. 327-343, 2014. doi:10.1155/2014/340586
dc.identifier.urihttp://dx.doi.org/10.1155/2014/340586
dc.identifier.urihttp://hdl.handle.net/1993/31333
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2014 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleTherapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective
dc.typeJournal Article
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