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dc.contributor.supervisor Zhong, Wen (Textile Sciences) Xing, Malcolm (Mechanical Engineering) en_US
dc.contributor.author Shi, Junbin
dc.date.accessioned 2012-08-03T14:50:08Z
dc.date.available 2012-08-03T14:50:08Z
dc.date.issued 2012-08-03
dc.identifier.uri http://hdl.handle.net/1993/8149
dc.description.abstract This thesis includes two parts related to hydrogels as therapeutically useful constructs: a biomimetic hydrogel carrying stem cells for bone regeneration and an acid-sensitive hydrogel carrying drugs for cancer therapy. In tissue engineering, one of the biggest difficulties is the control of stem cell fate on scaffolds. A biodegradable and cell attachable cross-linker was synthesized by one-step Michael additional reaction, and was used to fabricate a novel hydrogel to control the stem cell fate. For anti-cancer therapy, releasing drug on tumor cells or organs while having low effects on health cells under physiological conditions is a critical requirement. Two nature polymers are modified to achieve loading anti-cancer drug while forming hydrogels which can selectively release the drug in tumor environment by acid-sensitive linkages. en_US
dc.subject Hydrogels en_US
dc.subject Environment-responsive en_US
dc.subject Stem cells en_US
dc.subject Cancer therapy en_US
dc.title Development of Environment-Responsive Hydrogels for the Delivery of Therapeutic Agents en_US
dc.degree.discipline Textile Sciences en_US
dc.contributor.examiningcommittee Chen, Ying (Biosystems Engineering) King, Martin (Textile Sciences) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2012 en_US


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