Show simple item record

dc.contributor.supervisorZhong, Wen (Textile Sciences) Xing, Malcolm (Mechanical Engineering)en_US
dc.contributor.authorShi, Junbin
dc.date.accessioned2012-08-03T14:50:08Z
dc.date.available2012-08-03T14:50:08Z
dc.date.issued2012-08-03
dc.identifier.urihttp://hdl.handle.net/1993/8149
dc.description.abstractThis thesis includes two parts related to hydrogels as therapeutically useful constructs: a biomimetic hydrogel carrying stem cells for bone regeneration and an acid-sensitive hydrogel carrying drugs for cancer therapy. In tissue engineering, one of the biggest difficulties is the control of stem cell fate on scaffolds. A biodegradable and cell attachable cross-linker was synthesized by one-step Michael additional reaction, and was used to fabricate a novel hydrogel to control the stem cell fate. For anti-cancer therapy, releasing drug on tumor cells or organs while having low effects on health cells under physiological conditions is a critical requirement. Two nature polymers are modified to achieve loading anti-cancer drug while forming hydrogels which can selectively release the drug in tumor environment by acid-sensitive linkages.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydrogelsen_US
dc.subjectEnvironment-responsiveen_US
dc.subjectStem cellsen_US
dc.subjectCancer therapyen_US
dc.titleDevelopment of Environment-Responsive Hydrogels for the Delivery of Therapeutic Agentsen_US
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineTextile Sciencesen_US
dc.contributor.examiningcommitteeChen, Ying (Biosystems Engineering) King, Martin (Textile Sciences)en_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteOctober 2012en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record