Development of Environment-Responsive Hydrogels for the Delivery of Therapeutic Agents
| dc.contributor.author | Shi, Junbin | |
| dc.contributor.examiningcommittee | Chen, Ying (Biosystems Engineering) King, Martin (Textile Sciences) | en_US |
| dc.contributor.supervisor | Zhong, Wen (Textile Sciences) Xing, Malcolm (Mechanical Engineering) | en_US |
| dc.date.accessioned | 2012-08-03T14:50:08Z | |
| dc.date.available | 2012-08-03T14:50:08Z | |
| dc.date.issued | 2012-08-03 | |
| dc.degree.discipline | Textile Sciences | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | This thesis includes two parts related to hydrogels as therapeutically useful constructs: a biomimetic hydrogel carrying stem cells for bone regeneration and an acid-sensitive hydrogel carrying drugs for cancer therapy. In tissue engineering, one of the biggest difficulties is the control of stem cell fate on scaffolds. A biodegradable and cell attachable cross-linker was synthesized by one-step Michael additional reaction, and was used to fabricate a novel hydrogel to control the stem cell fate. For anti-cancer therapy, releasing drug on tumor cells or organs while having low effects on health cells under physiological conditions is a critical requirement. Two nature polymers are modified to achieve loading anti-cancer drug while forming hydrogels which can selectively release the drug in tumor environment by acid-sensitive linkages. | en_US |
| dc.description.note | October 2012 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/8149 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Hydrogels | en_US |
| dc.subject | Environment-responsive | en_US |
| dc.subject | Stem cells | en_US |
| dc.subject | Cancer therapy | en_US |
| dc.title | Development of Environment-Responsive Hydrogels for the Delivery of Therapeutic Agents | en_US |
| dc.type | master thesis | en_US |