The Potential Role of FREM1 and Its Isoform TILRR in HIV-1 Acquisition through Mediating Inflammation
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Date
2021-07-22
Authors
Kashem, Mohammad
Li, Hongzhao
Liu, Lewis
Liang, Binhua
Omange, Robert
Plummer, Francis
Luo, Ma
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
FREM1 (Fras-related extracellular matrix 1) and its splice variant TILRR (Toll-like interleukin-1 receptor regulator) have been identified as integral components of innate immune systems. The potential involvement of FREM1 in HIV-1 acquisition was suggested by a Genome-wide SNPs (single nucleotide polymorphisms) analysis of HIV-1 resistant and susceptible sex workers enrolled in the Pumwani sex worker cohort in Nairobi, Kenya. The studies showed that the minor allele of a FREM1 SNP rs1552896 is highly enriched in the HIV-1 resistant female sex workers. Subsequent studies showed that FREM1 mRNA is highly expressed in tissues relevant to mucosal HIV-1 infection, including cervical epithelial tissues, and TILRR is a major modulator of many genes in the NF-κB signal transduction pathway. In this article, we review the role of FREM1 and TILRR in modulating inflammatory responses and inflammation, and how their influence on in-flammatory responses of cervicovaginal tissue could enhance the risk of vaginal HIV-1 acquisition.
Description
Keywords
FREM1, TILRR, Inflammation, HIV-1 acquisition, Research Subject Categories::MEDICINE
Citation
Kashem, M.A.; Li, H.; Liu, L.R.; Liang, B.; Omange, R.W.; Plummer, F.A.; Luo, M. The Potential Role of FREM1 and Its Isoform TILRR in HIV-1 Acquisition through Mediating Inflammation. Int. J. Mol. Sci. 2021, 22, 7825. https://doi.org/ 10.3390/ijms22157825