The Potential Role of FREM1 and Its Isoform TILRR in HIV-1 Acquisition through Mediating Inflammation

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dc.contributor.authorKashem, Mohammad
dc.contributor.authorLi, Hongzhao
dc.contributor.authorLiu, Lewis
dc.contributor.authorLiang, Binhua
dc.contributor.authorOmange, Robert
dc.contributor.authorPlummer, Francis
dc.contributor.authorLuo, Ma
dc.date.accessioned2021-08-12T16:12:09Z
dc.date.available2021-08-12T16:12:09Z
dc.date.issued2021-07-22
dc.date.submitted2021-08-12T01:40:09Zen_US
dc.description.abstractFREM1 (Fras-related extracellular matrix 1) and its splice variant TILRR (Toll-like interleukin-1 receptor regulator) have been identified as integral components of innate immune systems. The potential involvement of FREM1 in HIV-1 acquisition was suggested by a Genome-wide SNPs (single nucleotide polymorphisms) analysis of HIV-1 resistant and susceptible sex workers enrolled in the Pumwani sex worker cohort in Nairobi, Kenya. The studies showed that the minor allele of a FREM1 SNP rs1552896 is highly enriched in the HIV-1 resistant female sex workers. Subsequent studies showed that FREM1 mRNA is highly expressed in tissues relevant to mucosal HIV-1 infection, including cervical epithelial tissues, and TILRR is a major modulator of many genes in the NF-κB signal transduction pathway. In this article, we review the role of FREM1 and TILRR in modulating inflammatory responses and inflammation, and how their influence on in-flammatory responses of cervicovaginal tissue could enhance the risk of vaginal HIV-1 acquisition.en_US
dc.identifier.citationKashem, M.A.; Li, H.; Liu, L.R.; Liang, B.; Omange, R.W.; Plummer, F.A.; Luo, M. The Potential Role of FREM1 and Its Isoform TILRR in HIV-1 Acquisition through Mediating Inflammation. Int. J. Mol. Sci. 2021, 22, 7825. https://doi.org/ 10.3390/ijms22157825en_US
dc.identifier.doiorg/ 10.3390/ijms22157825
dc.identifier.urihttp://hdl.handle.net/1993/35796
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsopen accessen_US
dc.subjectFREM1en_US
dc.subjectTILRRen_US
dc.subjectInflammationen_US
dc.subjectHIV-1 acquisitionen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleThe Potential Role of FREM1 and Its Isoform TILRR in HIV-1 Acquisition through Mediating Inflammationen_US
dc.typeArticleen_US
local.author.affiliationRady Faculty of Health Sciencesen_US
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