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dc.contributor.supervisor Leong, Christine (Pharmacy) en_US
dc.contributor.author Brandt, Jaden
dc.date.accessioned 2019-01-15T19:56:43Z
dc.date.available 2019-01-15T19:56:43Z
dc.date.issued 2018 en_US
dc.date.submitted 2018-12-22T19:46:59Z en
dc.date.submitted 2019-01-07T21:08:48Z en
dc.date.submitted 2019-01-15T17:20:58Z en
dc.identifier.citation Drugs R D 17(4) 493-507 en_US
dc.identifier.citation Clinical Drug Investigation 38(7) 565-572 en_US
dc.identifier.citation Journal of Population Therapeutics and Clinical Pharmacology 26(1) 1-17 en_US
dc.identifier.uri http://hdl.handle.net/1993/33722
dc.description.abstract Background: The use of benzodiazepines and z-drugs remains controversial given their potential for misuse and harm. Investigation of their use in Manitoba remains important for monitoring and improving prescribing patterns. Methods: Administrative data was used to conduct i) drug utilization study from 2001-2016, and ii) incident-user cohort study of patients with anxiety/insomnia. Results: i) Z-drug use increased on all measures while only dose intensity increased for benzodiazepines. Higher utilization occurred among females and those ≥65 years. ii) The proportion of patients who became long-term users (>6months) in their first episode of use ranged from 4.5-9.6%. Males, older age, socioeconomically deprived, use of opioids or psychotropic agents, and poor physical health, were associated with long-term use. Conclusion: While less than one in 10 were considered a long-term user of these agents, further investigation into whether specific factors associated with long-term use requires consideration during the prescribing of these agents is warranted. en_US
dc.subject Benzodiazepines en_US
dc.subject Epidemiology en_US
dc.subject Anxiety en_US
dc.subject Insomnia en_US
dc.subject Drug utilization en_US
dc.title Pharmacoepidemiology and drug utilization of benzodiazepines and z-drugs among adults in Manitoba, Canada en_US
dc.degree.discipline Pharmacy en_US
dc.contributor.examiningcommittee Alessi-Severini, Silvia (Pharmacy) Zelenitsky, Sheryl (Pharmacy) Singer, Alexander (Family Medicine) Chateau, Dan (Community Health Sciences) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2019 en_US


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