Pharmacoepidemiology and drug utilization of benzodiazepines and z-drugs among adults in Manitoba, Canada

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dc.contributor.authorBrandt, Jaden
dc.contributor.examiningcommitteeAlessi-Severini, Silvia (Pharmacy) Zelenitsky, Sheryl (Pharmacy) Singer, Alexander (Family Medicine) Chateau, Dan (Community Health Sciences)en_US
dc.contributor.supervisorLeong, Christine (Pharmacy)en_US
dc.date.accessioned2019-01-15T19:56:43Z
dc.date.available2019-01-15T19:56:43Z
dc.date.issued2018en_US
dc.date.submitted2018-12-22T19:46:59Zen
dc.date.submitted2019-01-07T21:08:48Zen
dc.date.submitted2019-01-15T17:20:58Zen
dc.degree.disciplinePharmacyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractBackground: The use of benzodiazepines and z-drugs remains controversial given their potential for misuse and harm. Investigation of their use in Manitoba remains important for monitoring and improving prescribing patterns. Methods: Administrative data was used to conduct i) drug utilization study from 2001-2016, and ii) incident-user cohort study of patients with anxiety/insomnia. Results: i) Z-drug use increased on all measures while only dose intensity increased for benzodiazepines. Higher utilization occurred among females and those ≥65 years. ii) The proportion of patients who became long-term users (>6months) in their first episode of use ranged from 4.5-9.6%. Males, older age, socioeconomically deprived, use of opioids or psychotropic agents, and poor physical health, were associated with long-term use. Conclusion: While less than one in 10 were considered a long-term user of these agents, further investigation into whether specific factors associated with long-term use requires consideration during the prescribing of these agents is warranted.en_US
dc.description.noteFebruary 2019en_US
dc.identifier.citationDrugs R D 17(4) 493-507en_US
dc.identifier.citationClinical Drug Investigation 38(7) 565-572en_US
dc.identifier.citationJournal of Population Therapeutics and Clinical Pharmacology 26(1) 1-17en_US
dc.identifier.urihttp://hdl.handle.net/1993/33722
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectBenzodiazepinesen_US
dc.subjectEpidemiologyen_US
dc.subjectAnxietyen_US
dc.subjectInsomniaen_US
dc.subjectDrug utilizationen_US
dc.titlePharmacoepidemiology and drug utilization of benzodiazepines and z-drugs among adults in Manitoba, Canadaen_US
dc.typemaster thesisen_US
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