Pattern of insulin delivery affects hepatic insulin sensitizing substance (HISS) action and insulin resistance
Date
2004-12-31
Authors
Reid, MAG
Lautt, WW
Journal Title
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Abstract
Hepatic insulin sensitizing substance (HISS) action accounts for 55% of the glucose disposal effect of a bolus of insulin in the fed state. To determine the effect of continuous versus pulsatile insulin delivery on HISS action in male Sprague-Dawley rats, insulin sensitivity was assessed using the rapid insulin sensitivity test (RIST) before and after a continuous, pulsatile, or bolus insulin (60 mU/kg i.v.) delivery. There was a significant difference in the RIST index after a continuous insulin infusion (247.9 mg/kg before, 73.2 mg/kg after) but not after 3 pulses where insulin action returned to baseline between pulses (211.6 mg/kg before, 191.0 mg/kg after) or single bolus (205.8 mg/kg before, 189.9 mg/kg after) insulin infusion. If a 3-pulse infusion was timed so that insulin action did not return to baseline between pulses, HISS action was suppressed. Continuous insulin infusion (10-30 min) showed progressive postinfusion blockade of HISS action. To maintain HISS-dependent insulin action, continuous insulin infusions should be avoided.
Description
Keywords
pulsatile, glucose uptake, RIST, euglycemic clamp, insulin sensitivity, SENSITIVITY TEST RIST, PULSATILE INSULIN, CHOLINERGIC BLOCKADE, GLUCOSE DISPOSAL, EUGLYCEMIC CLAMP, PULSE FREQUENCY, PLASMA-GLUCOSE, OSCILLATIONS, HYPERINSULINEMIA, SECRETION
Citation
0008-4212; CAN J PHYSIOL PHARMACOL, DEC 2004, vol. 82, no. 12, p.1068 to 1074.