Pattern of insulin delivery affects hepatic insulin sensitizing substance (HISS) action and insulin resistance

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dc.contributor.authorReid, MAG
dc.contributor.authorLautt, WW
dc.date.accessioned2008-01-21T18:41:04Z
dc.date.available2008-01-21T18:41:04Z
dc.date.issued2004-12-31
dc.description.abstractHepatic insulin sensitizing substance (HISS) action accounts for 55% of the glucose disposal effect of a bolus of insulin in the fed state. To determine the effect of continuous versus pulsatile insulin delivery on HISS action in male Sprague-Dawley rats, insulin sensitivity was assessed using the rapid insulin sensitivity test (RIST) before and after a continuous, pulsatile, or bolus insulin (60 mU/kg i.v.) delivery. There was a significant difference in the RIST index after a continuous insulin infusion (247.9 mg/kg before, 73.2 mg/kg after) but not after 3 pulses where insulin action returned to baseline between pulses (211.6 mg/kg before, 191.0 mg/kg after) or single bolus (205.8 mg/kg before, 189.9 mg/kg after) insulin infusion. If a 3-pulse infusion was timed so that insulin action did not return to baseline between pulses, HISS action was suppressed. Continuous insulin infusion (10-30 min) showed progressive postinfusion blockade of HISS action. To maintain HISS-dependent insulin action, continuous insulin infusions should be avoided.en
dc.format.extent304126 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citation0008-4212; CAN J PHYSIOL PHARMACOL, DEC 2004, vol. 82, no. 12, p.1068 to 1074.en
dc.identifier.doihttp://dx.doi.org/10.1139/y04-111
dc.identifier.urihttp://hdl.handle.net/1993/3013
dc.language.isoengen_US
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dc.rightsopen accessen_US
dc.statusPeer revieweden
dc.subjectpulsatileen
dc.subjectglucose uptakeen
dc.subjectRISTen
dc.subjecteuglycemic clampen
dc.subjectinsulin sensitivityen
dc.subjectSENSITIVITY TEST RISTen
dc.subjectPULSATILE INSULINen
dc.subjectCHOLINERGIC BLOCKADEen
dc.subjectGLUCOSE DISPOSALen
dc.subjectEUGLYCEMIC CLAMPen
dc.subjectPULSE FREQUENCYen
dc.subjectPLASMA-GLUCOSEen
dc.subjectOSCILLATIONSen
dc.subjectHYPERINSULINEMIAen
dc.subjectSECRETIONen
dc.titlePattern of insulin delivery affects hepatic insulin sensitizing substance (HISS) action and insulin resistanceen
dc.typejournal articleen_US
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