dc.contributor.author | Hosea, Heather J. | |
dc.contributor.author | Rector, Edward S. | |
dc.contributor.author | Taylor, Carla G. | |
dc.date.accessioned | 2014-08-14T07:06:37Z | |
dc.date.available | 2014-08-14T07:06:37Z | |
dc.date.issued | 2005-03 | |
dc.identifier.citation | Heather J. Hosea, Edward S. Rector, and Carla G. Taylor, “Age-related Changes in p56lck Protein Levels and Phenotypic Distribution of T Lymphocytes in Young Rats,” Clinical and Developmental Immunology, vol. 12, no. 1, pp. 75-84, 2005. doi:10.1080/17402520400017393 | |
dc.identifier.uri | http://hdl.handle.net/1993/23785 | |
dc.description.abstract | p56lck is involved in the maturation of T-cells from double negative
(DN) into double positive (DP) T-cells. The objective of this experiment was to
determine changes in the levels of thymic and splenic T-cell
p56lck using Western
immunoblotting, along with the proportion and number of T-cell subsets in thymus,
spleen and blood using flow cytometry in growing Sprague-Dawley rats. Thymic
p56lck levels were negatively correlated with age
(r=-0.42,
p=0.04) and positively
correlated with age in the spleen (r=0.50, p=0.01).
Nine-week-old rats had
a higher percentage of thymic DN and CD8 cells with fewer DP cells compared
to younger rats. There were minor differences in the proportions of T-cell subsets
in the spleen and blood. T-cell numbers remained proportional to body weight in
the lymphoid organs; however, the lower absolute number of
T-cells in the younger rats might indicate that they are less able to respond to antigens. | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Age-related Changes in p56lck Protein Levels and Phenotypic Distribution of T Lymphocytes in Young Rats | |
dc.type | Journal Article | |
dc.type | info:eu-repo/semantics/article | |
dc.language.rfc3066 | en | |
dc.description.version | Peer Reviewed | |
dc.rights.holder | Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.date.updated | 2014-08-14T07:06:37Z | |
dc.identifier.doi | http://dx.doi.org/10.1080/17402520400017393 | |