Show simple item record Hausner, Georg Hafez, Mohamed Edgell, David R 2014-04-10T07:39:17Z 2014-04-10T07:39:17Z 2014-03-10
dc.identifier.citation Mobile DNA. 2014 Mar 10;5(1):8
dc.description.abstract Abstract Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially renders their insertion into genes phenotypically neutral. Some group I introns are mobile genetic elements due to encoded homing endonuclease genes that function in DNA-based mobility pathways to promote spread to intronless alleles. Group I introns have a limited distribution among bacteria and the current assumption is that they are benign selfish elements, although some introns and homing endonucleases are a source of genetic novelty as they have been co-opted by host genomes to provide regulatory functions. Questions regarding the origin and maintenance of group I introns among the bacteria and phages are also addressed.
dc.rights info:eu-repo/semantics/openAccess
dc.title Bacterial group I introns: mobile RNA catalysts
dc.type Journal Article
dc.type info:eu-repo/semantics/article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Georg Hausner et al.; licensee BioMed Central Ltd. 2014-04-10T07:39:18Z

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