Bacterial group I introns: mobile RNA catalysts
| dc.contributor.author | Hausner, Georg | |
| dc.contributor.author | Hafez, Mohamed | |
| dc.contributor.author | Edgell, David R | |
| dc.date.accessioned | 2014-04-10T07:39:17Z | |
| dc.date.available | 2014-04-10T07:39:17Z | |
| dc.date.issued | 2014-03-10 | |
| dc.date.updated | 2014-04-10T07:39:18Z | |
| dc.description.abstract | Abstract Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially renders their insertion into genes phenotypically neutral. Some group I introns are mobile genetic elements due to encoded homing endonuclease genes that function in DNA-based mobility pathways to promote spread to intronless alleles. Group I introns have a limited distribution among bacteria and the current assumption is that they are benign selfish elements, although some introns and homing endonucleases are a source of genetic novelty as they have been co-opted by host genomes to provide regulatory functions. Questions regarding the origin and maintenance of group I introns among the bacteria and phages are also addressed. | |
| dc.description.version | Peer Reviewed | |
| dc.identifier.citation | Mobile DNA. 2014 Mar 10;5(1):8 | |
| dc.identifier.doi | http://dx.doi.org/10.1186/1759-8753-5-8 | |
| dc.identifier.uri | http://hdl.handle.net/1993/23424 | |
| dc.language.rfc3066 | en | |
| dc.rights | open access | en_US |
| dc.rights.holder | Georg Hausner et al.; licensee BioMed Central Ltd. | |
| dc.title | Bacterial group I introns: mobile RNA catalysts | |
| dc.type | Journal Article |
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