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A novel magnetic resonance imaging technique to assess tissue viability following acute myocardial infarction, simultaneous T1 and T2* signal intensity monitoring following bolus injected contrast agent

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dc.contributor.author Mark, John K. en_US
dc.date.accessioned 2007-05-18T20:00:33Z
dc.date.available 2007-05-18T20:00:33Z
dc.date.issued 2000-09-10T00:00:00Z en_US
dc.identifier.uri http://hdl.handle.net/1993/1842
dc.description.abstract This study was designed to determine whether injured myocardium can be identified by simultaneously monitoring contrast-induced T1 and T2* signal intensity changes with an interleaved T1-T2* imaging sequence and to compare these results to techniques that calculate relaxation rate following contrast agent injection. Eight pigs were subjected to 'in situ' coronary artery occlusion for 2 hours, followed by 1-hour of reperfusion. The hearts were then excised and imaged 'ex vivo'. Gadolinium-diethylene triamine pentaacetic acid (0.05 mmol/kg) was injected as a bolus and T1 and T2* signal intensities were monitored using alternating T1 and T2*-weighted imaging to obtain simultaneous T1 and T2* timecourses during the first pass. The T2* signal at maximum T1 signal intensity displayed a percentage recovery that was significantly different (p < 0.05) between normal (30.5 +- 2.4% of baseline value), reperfused-infarcted (63 +- 7.2%), and low-reflow infarcted myocardium (90 +- 2.8%) respectively. This may reflect differences in membrane integrity between regions. On the other hand, R1 and R2* relaxation rates did not show any significant difference (p > 0.05) in the low-reflow infarcted myocardium relative to normal tissue. These results suggest that observing contrast-enhanced R1 and R2* rates early after contrast injection cannot fully differentiate viable from non-viable myocardium, but simultaneously monitoring both T1 and T2* signal intensity may help in the assessment of myocardial injury. en_US
dc.format.extent 4448237 bytes
dc.format.extent 184 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language en en_US
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.title A novel magnetic resonance imaging technique to assess tissue viability following acute myocardial infarction, simultaneous T1 and T2* signal intensity monitoring following bolus injected contrast agent en_US
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Physiology en_US
dc.degree.level Master of Science (M.Sc.) en_US


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