A novel magnetic resonance imaging technique to assess tissue viability following acute myocardial infarction, simultaneous T1 and T2* signal intensity monitoring following bolus injected contrast agent

dc.contributor.authorMark, John K.en_US
dc.date.accessioned2007-05-18T20:00:33Z
dc.date.available2007-05-18T20:00:33Z
dc.date.issued2000-09-10T00:00:00Zen_US
dc.degree.disciplinePhysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThis study was designed to determine whether injured myocardium can be identified by simultaneously monitoring contrast-induced T1 and T2* signal intensity changes with an interleaved T1-T2* imaging sequence and to compare these results to techniques that calculate relaxation rate following contrast agent injection. Eight pigs were subjected to 'in situ' coronary artery occlusion for 2 hours, followed by 1-hour of reperfusion. The hearts were then excised and imaged 'ex vivo'. Gadolinium-diethylene triamine pentaacetic acid (0.05 mmol/kg) was injected as a bolus and T1 and T2* signal intensities were monitored using alternating T1 and T2*-weighted imaging to obtain simultaneous T1 and T2* timecourses during the first pass. The T2* signal at maximum T1 signal intensity displayed a percentage recovery that was significantly different (p < 0.05) between normal (30.5 +- 2.4% of baseline value), reperfused-infarcted (63 +- 7.2%), and low-reflow infarcted myocardium (90 +- 2.8%) respectively. This may reflect differences in membrane integrity between regions. On the other hand, R1 and R2* relaxation rates did not show any significant difference (p > 0.05) in the low-reflow infarcted myocardium relative to normal tissue. These results suggest that observing contrast-enhanced R1 and R2* rates early after contrast injection cannot fully differentiate viable from non-viable myocardium, but simultaneously monitoring both T1 and T2* signal intensity may help in the assessment of myocardial injury.en_US
dc.format.extent4448237 bytes
dc.format.extent184 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.urihttp://hdl.handle.net/1993/1842
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.titleA novel magnetic resonance imaging technique to assess tissue viability following acute myocardial infarction, simultaneous T1 and T2* signal intensity monitoring following bolus injected contrast agenten_US
dc.typemaster thesisen_US
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