Durability of amide N-chloramine biocides to ethylene oxide sterilization

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dc.contributor.authorZhao, Nan
dc.contributor.authorLogsetty, Sarvesh
dc.contributor.authorLiu, Song
dc.date.accessioned2018-10-05T21:01:45Z
dc.date.available2018-10-05T21:01:45Z
dc.date.issued2012-07-01
dc.date.submitted2018-10-05T20:16:13Zen
dc.description.abstractThe objective of this work is to study the stability of three novel topical antimicrobial dressings consisting of amide N-chloramine structures against ethylene oxide sterilization. Cotton gauze samples bonded with one of three amide N-chloramine structures were subjected to standard ethylene oxide (EtO) sterilization. The amounts of amide N-chloramine structures before and after the sterilization were quantified to indicate the stabilities of these amide N-chloramine structures to the sterilization. The samples after sterilization were challenged with a clinical isolate of healthcare-associated multidrug-resistant Escherichia coli. N-Chloramine structure converted from polymethacrylamide (dressing 2) had the highest durability (89.7% retained active chlorine) toward EtO sterilization; that from hydantoin (dressing 3; 86.3% retained active chlorine) followed; and poly(N-chloroacrylamide) (dressing 1) had the lowest (64.0% retained active chlorine). After EtO sterilization, all the samples still reduced E. coli presence at 5 minutes of contact, with dressing 2 retaining a log 6 reduction. The three tested amide N-chloramine structures could all survive EtO sterilization while retaining percentages of active chlorine ranging from 64.0 to 89.7%. Dressing 2 showed the best durability, whereas dressing 1 had the poorest durability. With the remaining amounts of amide N-chloramine structures after EtO sterilization, all the dressings could still reduce E. coli numbers within 5 minutes of contact, and dressing 2 resulted in a log 6 reduction in colony count.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (RGPIN/372048-2009)en_US
dc.identifier.citationZhao, N.; Logsetty, S.; Liu, S.* Durability of amide N-chloramine biocides to ethylene oxide sterilization. Journal of Burn Care and Research, 2012; 33(4): e201-6en_US
dc.identifier.doi10.1097/BCR.0b013e318241b31f
dc.identifier.urihttp://hdl.handle.net/1993/33525
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsopen accessen_US
dc.subjectN-Chloramineen_US
dc.subjectbiocidesen_US
dc.subjectEthylene Oxide Sterilizationen_US
dc.subjectantimicrobial wound dressingsen_US
dc.titleDurability of amide N-chloramine biocides to ethylene oxide sterilizationen_US
dc.typeArticleen_US
local.author.affiliationFaculty of Agricultural and Food Sciencesen_US
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