Durability of amide N-chloramine biocides to ethylene oxide sterilization
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Date
2012-07-01
Authors
Zhao, Nan
Logsetty, Sarvesh
Liu, Song
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
The objective of this work is to study the stability of three novel topical antimicrobial dressings
consisting of amide N-chloramine structures against ethylene oxide sterilization. Cotton gauze
samples bonded with one of three amide N-chloramine structures were subjected to standard
ethylene oxide (EtO) sterilization. The amounts of amide N-chloramine structures before and
after the sterilization were quantified to indicate the stabilities of these amide N-chloramine
structures to the sterilization. The samples after sterilization were challenged with a clinical
isolate of healthcare-associated multidrug-resistant Escherichia coli. N-Chloramine structure
converted from polymethacrylamide (dressing 2) had the highest durability (89.7% retained
active chlorine) toward EtO sterilization; that from hydantoin (dressing 3; 86.3% retained active
chlorine) followed; and poly(N-chloroacrylamide) (dressing 1) had the lowest (64.0% retained
active chlorine). After EtO sterilization, all the samples still reduced E. coli presence at 5 minutes
of contact, with dressing 2 retaining a log 6 reduction. The three tested amide N-chloramine
structures could all survive EtO sterilization while retaining percentages of active chlorine
ranging from 64.0 to 89.7%. Dressing 2 showed the best durability, whereas dressing 1 had the
poorest durability. With the remaining amounts of amide N-chloramine structures after EtO
sterilization, all the dressings could still reduce E. coli numbers within 5 minutes of contact, and
dressing 2 resulted in a log 6 reduction in colony count.
Description
Keywords
N-Chloramine, biocides, Ethylene Oxide Sterilization, antimicrobial wound dressings
Citation
Zhao, N.; Logsetty, S.; Liu, S.* Durability of amide N-chloramine biocides to ethylene oxide sterilization. Journal of Burn Care and Research, 2012; 33(4): e201-6