Bacteria-triggered release of a potent biocide from core-shell polyhydroxyalkanoate (PHA)-based nanofibers for wound dressing application

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dc.contributor.authorLi, Wei
dc.contributor.examiningcommitteeLevin, David (Biosystems Engineering) Logsetty, Sarvesh (Surgery)en_US
dc.contributor.supervisorLiu, Song (Biosystems Engineering) Cicek, Nazim (Biosystems Engineering)en_US
dc.date.accessioned2018-09-27T18:25:59Z
dc.date.available2018-09-27T18:25:59Z
dc.date.issued2018-09-25en_US
dc.date.submitted2018-09-14T22:17:58Zen
dc.date.submitted2018-09-25T16:20:18Zen
dc.degree.disciplineBiosystems Engineeringen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractBacterial infection is a serious issue in wound healing. Extensive use of biocides in wound dressings have raised concerns like biocide resistance and unwanted harm to normal skin cells. In this thesis, I report a new approach to realize bacteria-triggered release of biocide to the sites of bacterial infections from core-shell polyhydroxyalkanoate (PHA)-based nanofibers prepared by coaxial electrospinning. The hydrophobic PHA-based shell can effectively prevent the biocide from undesirable payload release in physiological environments without pathogens. However, in the presence of pathogens, the PHA-based shell is degraded by pathogens, and the encapsulated biocide is released. The released biocide subsequently can impose targeted antimicrobial effects on the bacteria. Using Pseudomonas aeruginosa as a model bacterium and dodecyltrimethylammonium chloride as a model biocide, we demonstrated that the core-shell PHA-based nanofibers released encapsulated dodecyltrimethylammonium chloride in the presence of Pseudomonas aeruginosa, resulting in targeted inhibition of Pseudomonas aeruginosa growth.en_US
dc.description.noteFebruary 2019en_US
dc.identifier.citationLi, W., Cicek, N., Levin, D. B., & Liu, S. (2018). Enabling electrospinning of medium-chain length polyhydroxyalkanoates (PHAs) by blending with short-chain length PHAs. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-11. doi: 10.1080/00914037.2018.1466136en_US
dc.identifier.urihttp://hdl.handle.net/1993/33473
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectPolyhydroxyalkanoatesen_US
dc.subjectNanofibersen_US
dc.subjectElectrospinningen_US
dc.subjectWound dressing applicationen_US
dc.titleBacteria-triggered release of a potent biocide from core-shell polyhydroxyalkanoate (PHA)-based nanofibers for wound dressing applicationen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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