Hepatitis E virus seroprevalence in Canada

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dc.contributor.authorWeger, Steven
dc.contributor.examiningcommitteeBall, Blake (Medical Microbiology and Infectious Diseases) Kaita, Kelly (Internal Medicine)en_US
dc.contributor.supervisorAndonov, Anton (Medical Microbiology and Infectious Diseases)en_US
dc.date.accessioned2017-02-02T17:26:44Z
dc.date.available2017-02-02T17:26:44Z
dc.date.issued2016
dc.degree.disciplineMedical Microbiology and Infectious Diseasesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractHepatitis E virus (HEV) is the main cause of acute viral hepatitis worldwide, predominantly in developing areas where it is endemic. Recently, HEV has gained more attention in the developed world, prompting several industrialized countries to assess seroprevalence rates using blood donor samples. The seroprevalence among Canadian blood donor samples collected from July 2013 - December 2015 was 5.84% (240/4,107). None of the 14,053 samples tested were positive for HEV RNA. There was no significant increase in the high-risk groups we tested. HIV was determined to be a significant risk-factor for HEV infection in a retrospective study of Kenya-based sex-worker cohorts, but not so in a Canadian cohort of HIV-positive intravenous drug users. Overall, HEV seroprevalence in Canada is lower than that published in other countries. This together with failing to detect HEV RNA in Canadian blood donations indicates that HEV currently poses low risk to the Canadian blood supply.en_US
dc.description.noteFebruary 2017en_US
dc.identifier.urihttp://hdl.handle.net/1993/32088
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectHepatitis E, HEV, Seroprevalence, Blood borneen_US
dc.titleHepatitis E virus seroprevalence in Canadaen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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