Characterizing the prevalence of chromosomal instability in interval colorectal cancer

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dc.contributor.authorCisyk, Amy L.
dc.contributor.examiningcommitteeLeygue, Etienne (Biochemistry and Medical Genetics) Mai, Sabine (Biochemistry and Medical Genetics) Singh, Harminder (Internal Medicine)en_US
dc.contributor.supervisorMcManus, Kirk (Biochemistry and Medical Genetics)en_US
dc.date.accessioned2014-01-10T20:30:05Z
dc.date.available2014-01-10T20:30:05Z
dc.date.issued2014-01-10
dc.degree.disciplineBiochemistry and Medical Geneticsen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractOver 80% of colorectal cancers (CRCs) are sporadic/randomly arising tumors. Interval CRCs represent a subset of sporadic tumors that develop within 6-36 months after a negative colonoscopy. Interval CRCs are suggested to exhibit altered biological properties that contribute to rapid growth and proliferation. We hypothesize that chromosomal instability (CIN), or aberrant chromosome numbers, contributes to the etiology of Interval CRCs. We have assembled a Manitoban cohort of Interval and sporadic (control) CRC tumor samples, and established a fluorescence in situ hybridization approach to characterize CIN by enumerating specific chromosomes. The results of this study indicate that 75% of Interval CRCs exhibit a CIN phenotype, making CIN the most prevalent contributor to genomic instability in Interval CRCs. Only once we grasp a better understanding of the tumorigenic pathways through which Interval CRCs develop, can we tailor screening strategies and treatment options to specifically identify and combat this subset of sporadic CRC.en_US
dc.description.noteFebruary 2014en_US
dc.identifier.urihttp://hdl.handle.net/1993/23148
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectInterval Colorectal Canceren_US
dc.subjectColonoscopyen_US
dc.subjectFalse-negativeen_US
dc.subjectChromosomal Instabilityen_US
dc.subjectSSA/Pen_US
dc.subjectColorectal Canceren_US
dc.subjectSerrated Adenomaen_US
dc.titleCharacterizing the prevalence of chromosomal instability in interval colorectal canceren_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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