Urinary biomarkers of renal transplant outcome

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dc.contributor.authorHo, Julie
dc.contributor.authorRush, David
dc.contributor.authorNickerson, Peter
dc.date.accessioned2020-09-11T22:00:21Z
dc.date.available2020-09-11T22:00:21Z
dc.date.issued2015-08
dc.date.submitted2020-09-11T17:33:54Zen_US
dc.description.abstractPurpose of review: Renal allograft loss remains an important cause of morbidity and mortality. The objective of this review was to provide a rationale for noninvasive monitoring to identify patients at high risk for graft loss; discuss key steps in prognostic biomarker development from bench-to-bedside; and review promising biomarkers for late renal allograft outcomes. Recent findings: In a multicentre prospective cohort, early 6-month urinary CCL2 was demonstrated to be associated with the development of 24-month interstitial fibrosis/tubular atrophy and inflammation (IFTAĆ¾i). These findings were extended to a single centre cohort, which showed that 6-month urinary CCL2 was a predictor of death-censored graft loss independent of donor-specific antibody and delayed graft function. In a large, multicentre prospective observational study (CTOT-01), 6-month urinary CXCL9 was significantly associated with more than 30% decline of graft function at 24 months. Summary: Urinary chemokines may identify recipients who are at high risk of graft loss. The early detection of high risk recipients may allow for more intensive posttransplant surveillance; avoidance of drug minimization/withdrawal protocols; and the identification of patients who may benefit from enrolment in novel interventional trials. Prospective trials are needed to demonstrate that urinary chemokine-guided posttransplant surveillance strategies improve long-term graft outcomes.en_US
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR grant 287559), CIHR grant 310533. Manitoba Medical Services Foundation Dr FW Du Val Clinical Research Professorship. Flynn Family Chair in Renal Transplantation, University of Manitoba.en_US
dc.identifier.citationCurr Opin Organ Transplant 20(4):476-481, 2015en_US
dc.identifier.doi10.1097/MOT.0000000000000208
dc.identifier.urihttp://hdl.handle.net/1993/35053
dc.language.isoengen_US
dc.publisherWolters Kluwer Healthen_US
dc.rightsopen accessen_US
dc.subjectCCL2en_US
dc.subjectCXCL10en_US
dc.subjectCXCL9en_US
dc.subjectnoninvasive monitoringen_US
dc.subjectposttransplant surveillanceen_US
dc.subjecturine microRNAen_US
dc.titleUrinary biomarkers of renal transplant outcomeen_US
dc.typeresearch articleen_US
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