Establishment of a tissue bank for human fetal lungs of congenital diaphragmatic hernia patients

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dc.contributor.authorAyoub, Lojine
dc.contributor.examiningcommitteeDakshinamurti, Shyamala (Physiology and Pathophysiology) Del Bigio, Marc (Pathology)en_US
dc.contributor.supervisorKeijzer, Richard (Physiology and Pathophysiology)en_US
dc.date.accessioned2018-01-09T19:47:18Z
dc.date.available2018-01-09T19:47:18Z
dc.date.issued2017
dc.degree.disciplinePhysiology and Pathophysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractStatement of problem: Congenital Diaphragmatic Hernia (CDH) is a fatal disease associated with abnormal lung development. Our aim is to establish a clinical database coupled with a biobank for CDH patients to facilitate further research. Methods: Our database and tissue bank were formed from the Pathology autopsy database for the CDH non-survivors and control subjects. We compared our database with CDH survivors records from a separate REDCap clinical CDH database. Results: The study comprised a total of 155 subjects, of which, 99 were CDH survivors, 40 were CDH non-survivors, and 16 were deceased subjects without CDH used as controls. Seventeen lung tissue blocks with different stages of lung development were obtained. Male subjects (59.7%) and left-sided CDH (76.9%) were more common. Among non-survivors we found a lower lung-to-body-weight (mean value 0.008 ± 0.004) compared to controls (0.019 ± 0.006). Conclusion: This clinical database and tissue bank can help future research.en_US
dc.description.noteFebruary 2018en_US
dc.identifier.urihttp://hdl.handle.net/1993/32751
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectCongenital diaphragmatic herniaen_US
dc.subjectCDHen_US
dc.subjectHypoplastic lungsen_US
dc.subjectHuman fetal lungsen_US
dc.subjectTissue banken_US
dc.titleEstablishment of a tissue bank for human fetal lungs of congenital diaphragmatic hernia patientsen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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