Follow up study of “atypical” prostate needle core biopsies; the Winnipeg experience and literature review
| dc.contributor.author | Lam, Wai Mei Lindsay | |
| dc.contributor.examiningcommittee | Myal, Yvonne (Pathology) Drachenburg, Darrel (Surgery) | en_US |
| dc.contributor.supervisor | Wightman, Robert (Pathology) | en_US |
| dc.date.accessioned | 2014-01-13T18:59:28Z | |
| dc.date.available | 2014-01-13T18:59:28Z | |
| dc.date.issued | 2014-01-13 | |
| dc.degree.discipline | Pathology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | High grade intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) are two pathological lesions associated with prostate adenocarcinoma. HGPIN is an architectural finding, while ASAP is a term used to describe a lesion that cannot confidently be diagnosed as prostate adenocarcinoma. The mean incidence rate for HGPIN is 7.7% with a median of 5.2% and range of 0-24.6% and the cancer detection rate mean is 18.1%. The mean incidence rate for ASAP is 5.0% with a median of 4.4% and a range of 0.7-23.4%. The mean cancer detection rate is 40.2%. Currently, the incidence and cancer detection rates for HGPIN and ASAP for Winnipeg, Manitoba, have not been published. A retrospective study was conducted on all prostate biopsies collected from the Manitoba Cancer Care Prostate Centre (MCCPC) from 2008 and 2009. Prostate biopsies with a diagnosis of isolated HGPIN and or ASAP and no previous history of cancer were included in this study. In Winnipeg, Manitoba, from 2008-2009, the mean HGPIN incidence rate was 5.0% and the mean cancer detection rate was 46.1%. The mean ASAP incidence rate was 4.6% and the mean cancer detection rate of 48.2%. As a control, the cancer detection rate following a benign diagnosis was also calculated at 33.3%. The mean incidence and cancer detection rates for HGPIN and ASAP for Winnipeg, Manitoba are slightly lower than literature, but still fall within the published range. In addition, the mean ASAP cancer detection rate is similar to the cancer detection rate following a benign diagnosis indicating that, in our study, both a benign finding and a diagnosis of ASAP hold the same predictive value for cancer on a subsequent re-biopsy. | en_US |
| dc.description.note | February 2014 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/23156 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | prostate | en_US |
| dc.subject | prostate adenocarcinoma | en_US |
| dc.subject | high-grade prostatic intraepithelial neoplasia | en_US |
| dc.subject | atypical small acinar proliferation | en_US |
| dc.title | Follow up study of “atypical” prostate needle core biopsies; the Winnipeg experience and literature review | en_US |
| dc.type | master thesis | en_US |
| local.subject.manitoba | yes | en_US |