New Biocide with Both N -Chloramine and Quaternary Ammonium Moieties Exerts Enhanced Bactericidal Activity

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dc.contributor.authorLi, Lingdong
dc.contributor.authorPu, Tianyun
dc.contributor.authorZhanel, George
dc.contributor.authorZhao, Nan
dc.contributor.authorEns, Werner
dc.contributor.authorLiu, Song
dc.date.accessioned2018-10-05T21:21:40Z
dc.date.available2018-10-05T21:21:40Z
dc.date.issued2012-07-03
dc.date.submitted2018-10-05T21:13:19Zen
dc.description.abstractConsidering the rise of antibiotic resistance, the development of new antibacterial agents with improved biocidal functions is urgently required. In this study, ionic 5,5-dimethylhydantoin (DMH) analogues containing either a quaternary ammonium moiety (2)–4) or a phosphonate functional group (5),–6), were designed and synthesized to investigate the possible enhancing effect of quaternary ammonium moieties on the antibacterial performance of N -chloramines. These ionic DMH analogues were converted to their N- chloramine counterparts either in free form or after being covalently immobilized on a polymer surface via the “click” chemistry method. In the subsequent antimicrobial assessment against multi-drug-resistant Escherichia coli (MDRE. coli ) and methicillin-resistant Staphylococcus aureus (MRSA), chlorinated 2 and 3, the cyclic N -chloramines with a structural cation, exhibited distinctly enhanced biocidal functions in solution and after immobilization on surfaces.en_US
dc.description.sponsorshipthe Manitoba Health Research Council (MHRC) Establishment grant the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (Grant No. RGPIN/372048-2009)en_US
dc.identifier.citationLi, L.; Pu, T.; Zhanel, G.G.; Zhao, N.; Ens, W.; Liu, S.* New Biocide with Both N-Chloramine and Quaternary Ammonium Salt Moieties Exerts Enhanced Bactericidal Activity. Advanced Healthcare Materials, 2012; 1(5): 609-620.en_US
dc.identifier.doi10.1002/adhm.201200018
dc.identifier.urihttp://hdl.handle.net/1993/33527
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsopen accessen_US
dc.subjectN-Chloramineen_US
dc.subjectQuaternary Ammoniumen_US
dc.subjectbiocidesen_US
dc.titleNew Biocide with Both N -Chloramine and Quaternary Ammonium Moieties Exerts Enhanced Bactericidal Activityen_US
dc.typeArticleen_US
local.author.affiliationFaculty of Agricultural and Food Sciencesen_US
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