New Biocide with Both N -Chloramine and Quaternary Ammonium Moieties Exerts Enhanced Bactericidal Activity
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Date
2012-07-03
Authors
Li, Lingdong
Pu, Tianyun
Zhanel, George
Zhao, Nan
Ens, Werner
Liu, Song
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Considering the rise of antibiotic resistance, the development of new antibacterial
agents with improved biocidal functions is urgently required. In
this study, ionic 5,5-dimethylhydantoin (DMH) analogues containing either
a quaternary ammonium moiety (2)–4) or a phosphonate functional group
(5),–6), were designed and synthesized to investigate the possible enhancing
effect of quaternary ammonium moieties on the antibacterial performance of
N -chloramines. These ionic DMH analogues were converted to their N- chloramine
counterparts either in free form or after being covalently immobilized
on a polymer surface via the “click” chemistry method. In the subsequent
antimicrobial assessment against multi-drug-resistant Escherichia coli (MDRE.
coli ) and methicillin-resistant Staphylococcus aureus (MRSA), chlorinated
2 and 3, the cyclic N -chloramines with a structural cation, exhibited distinctly
enhanced biocidal functions in solution and after immobilization on surfaces.
Description
Keywords
N-Chloramine, Quaternary Ammonium, biocides
Citation
Li, L.; Pu, T.; Zhanel, G.G.; Zhao, N.; Ens, W.; Liu, S.* New Biocide with Both N-Chloramine and Quaternary Ammonium Salt Moieties Exerts Enhanced Bactericidal Activity. Advanced Healthcare Materials, 2012; 1(5): 609-620.