Oxidative stress and neuronal changes associated with prenatal ethanol exposure in human and monkey brains
| dc.contributor.author | Basalah, Duaa Ali | |
| dc.contributor.examiningcommittee | Krawitz, Sherry (Pathology) Rastegar, Mojgan (Biochemistry & Medical Genetics) | en_US |
| dc.contributor.supervisor | Del Bigio, Marc R. (Pathology) | en_US |
| dc.date.accessioned | 2015-04-06T20:47:29Z | |
| dc.date.available | 2015-04-06T20:47:29Z | |
| dc.date.issued | 2015-04-06 | |
| dc.degree.discipline | Pathology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Background: Prenatal ethanol exposure (PNEE) causes irreversible intellectual and behavioral disabilities, clinically known as fetal alcohol spectrum disorder. Few neuropathologic studies of human brain exist. Hypotheses: First, markers of oxidative stress persist following PNEE. Second, PNEE is associated with inhibitory and excitatory neuron changes. Methods: Human brain autopsies (153) with known PNEE were reviewed; 18 cases (fetus to adult) and controls were selected. Oxidative stress and neuronal differentiation markers were used for immunohistochemistry. Results: There were no obvious differences between control and PNEE brains using oxidative stress markers. In human PNEE brains, glutamatergic neurons were reduced 15.96 % and 18.03% in dentate gyrus and temporal cortex, respectively. GABAergic neurons reactive for parvalbumin were reduced in all hippocampal regions (CA1= 57.86%, CA3= 65.15%, and DG= 53.39%) and temporal cortex (44.13%) in all age groups. Conclusion: GABAergic neuron reduction in human following PNEE could explain motor and behavior distractibility in FASD individuals. | en_US |
| dc.description.note | May 2015 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/30346 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Prenatal Ethanol Exposure | en_US |
| dc.subject | Fetal Alcohol Spectrum Disorders | en_US |
| dc.title | Oxidative stress and neuronal changes associated with prenatal ethanol exposure in human and monkey brains | en_US |
| dc.type | master thesis | en_US |