Surface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Technique

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dc.contributor.authorLi, Jiang
dc.contributor.authorLin, Francis
dc.contributor.authorLi, Lingdong
dc.contributor.authorLi, Jing
dc.contributor.authorLiu, Song
dc.date.accessioned2018-10-09T15:18:28Z
dc.date.available2018-10-09T15:18:28Z
dc.date.issued2012-05-08
dc.date.submitted2018-10-05T21:28:38Zen
dc.description.abstractHeparin was covalently bonded on chemically inert PET substrate using a surface modifi cation technique–surface interpenetrating network with the purpose of fabricating long-lasting biocompatible materials as vascular grafts. FTIR and XPS spectra confi rmed the successful heparinization of PET (PET-Hep). The density of surface-immobilized heparin as quantifi ed by a colorimetric method could reach 2.4 μ g cm − 2 (in the reported optimal range: 1.5–3.0 μ g cm − 2 ). The hemocompatibility of the heparin-immobilized PET was improved as evidenced by a platelet adhesion test: signifi cantly less platelet adhesion on PET-Hep (11.60%) than on untreated PET (48.91%). An MTT assay indicated PET-Hep was nontoxic to human dermal fi broblast cells. After an initial 5.24% loss of heparin from PETHep in the fi rst 14 h immersion in PBS buffer solution, no further leaching of heparin was found.en_US
dc.description.sponsorshipthe Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (Grant no.:RGPIN/372048-2009) the Manitoba Health Research Council (MHRC) Establishment grant.en_US
dc.identifier.citationLi, J.; Lin, F.; Li, L.; Li, J.; Liu, S.* Surface engineering of poly(ethylene terephthalate) for durable hemocompatibility via a surface interpenetrating network technique. Macromolecular Chemistry and Physics, 2012; 213(20): 2120–2129.en_US
dc.identifier.doi10.1002/macp.201200251
dc.identifier.urihttp://hdl.handle.net/1993/33530
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsopen accessen_US
dc.subjectSurface Engineering of Poly(ethylene terephthalate)en_US
dc.subjectSurface Interpenetrating Networken_US
dc.subjectDurable Hemocompatibilityen_US
dc.titleSurface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Techniqueen_US
dc.typeArticleen_US
local.author.affiliationFaculty of Agricultural and Food Sciencesen_US
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