Surface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Technique
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Date
2012-05-08
Authors
Li, Jiang
Lin, Francis
Li, Lingdong
Li, Jing
Liu, Song
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Heparin was covalently bonded on chemically inert PET substrate using a surface modifi cation
technique–surface interpenetrating network with the purpose of fabricating long-lasting
biocompatible materials as vascular grafts. FTIR and XPS spectra confi rmed the successful
heparinization of PET (PET-Hep). The density of surface-immobilized heparin as quantifi ed by
a colorimetric method could reach 2.4 μ g cm − 2 (in the reported
optimal range: 1.5–3.0 μ g cm − 2 ). The hemocompatibility of
the heparin-immobilized PET was improved as evidenced
by a platelet adhesion test: signifi cantly less platelet adhesion
on PET-Hep (11.60%) than on untreated PET (48.91%). An
MTT assay indicated PET-Hep was nontoxic to human dermal
fi broblast cells. After an initial 5.24% loss of heparin from PETHep
in the fi rst 14 h immersion in PBS buffer solution, no further
leaching of heparin was found.
Description
Keywords
Surface Engineering of Poly(ethylene terephthalate), Surface Interpenetrating Network, Durable Hemocompatibility
Citation
Li, J.; Lin, F.; Li, L.; Li, J.; Liu, S.* Surface engineering of poly(ethylene terephthalate) for durable hemocompatibility via a surface interpenetrating network technique. Macromolecular Chemistry and Physics, 2012; 213(20): 2120–2129.