Improving the prognosis of patients with Staphylococcus aureus bloodstream infections: A multifaceted treatment analysis

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dc.contributor.authorWeber, Zhanni
dc.contributor.examiningcommitteeAriano, Robert (Pharmacy) Lagace-Wiens, Philippe (Medical Microbiology) Vercaigne, Lavern (Pharmacy)en_US
dc.contributor.supervisorZelenitsky, Sheryl (Pharmacy)en_US
dc.date.accessioned2015-01-13T20:57:49Z
dc.date.available2015-01-13T20:57:49Z
dc.date.issued2015-01-13
dc.degree.disciplinePharmacyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThe treatment of Staphylococcus aureus bloodstream infections (SABSI) remains a major challenge. With an emphasis on complicated methicillin–sensitive S. aureus (MSSA), a comprehensive analysis of initial antibiotic treatment was conducted. The influence of treatment gaps on clinical outcomes were examined. Strategies were developed to improve the use of available antibiotics. Patient- and infection-related variables predictive for end-of-treatment failure included higher Charlson Comorbidity Index and healthcare-associated infection. Treatment variables of shorter duration of optimal targeted, shorter duration of optimal or adequate and lower TSE score were also predictive for end-of-treatment failure when tested separately in their own models. Strategies to optimize the treatment of complicated MSSA BSI at minimum should include: 1) Initiating at least an adequate therapy within 24 hours following the index blood culture draw and 2) Maintaining uninterrupted treatment, especially during the initial 7 days including at least 4 days of cloxacillin or cefazolin.en_US
dc.description.noteFebruary 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/30215
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectStaphylococcusen_US
dc.subjectaureusen_US
dc.subjectbloodstreamen_US
dc.subjectinfectionsen_US
dc.subjectantibioticen_US
dc.subjecttreatmenten_US
dc.titleImproving the prognosis of patients with Staphylococcus aureus bloodstream infections: A multifaceted treatment analysisen_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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