Renal Insufficiency and Early Bystander CPR Predict In-Hospital Outcomes in Cardiac Arrest Patients Undergoing Mild Therapeutic Hypothermia and Cardiac Catheterization: Return of Spontaneous Circulation, Cooling, and Catheterization Registry (ROSCCC Registry)

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dc.contributor.authorChelvanathan, Anjala
dc.contributor.authorAllen, David
dc.contributor.authorBews, Hilary
dc.contributor.authorDucas, John
dc.contributor.authorMinhas, Kunal
dc.contributor.authorVo, Minh
dc.contributor.authorKass, Malek
dc.contributor.authorRavandi, Amir
dc.contributor.authorTam, James W.
dc.contributor.authorJassal, Davinder S.
dc.contributor.authorHussain, Farrukh
dc.date.accessioned2016-05-11T15:12:04Z
dc.date.available2016-05-11T15:12:04Z
dc.date.issued2016-1-18
dc.date.updated2016-05-08T09:32:20Z
dc.description.abstractObjective. Out of hospital cardiac arrest (OHCA) patients are a critically ill patient population with high mortality. Combining mild therapeutic hypothermia (MTH) with early coronary intervention may improve outcomes in this population. The aim of this study was to evaluate predictors of mortality in OHCA patients undergoing MTH with and without cardiac catheterization. Design. A retrospective cohort of OHCA patients who underwent MTH with catheterization (MTH + C) and without catheterization (MTH + NC) between 2006 and 2011 was analyzed at a single tertiary care centre. Predictors of in-hospital mortality and neurologic outcome were determined. Results. The study population included 176 patients who underwent MTH for OHCA. A total of 66 patients underwent cardiac catheterization (MTH + C) and 110 patients did not undergo cardiac catheterization (MTH + NC). Immediate bystander CPR occurred in approximately half of the total population. In the MTH + C and MTH + NC groups, the in-hospital mortality was 48% and 78%, respectively. The only independent predictor of in-hospital mortality for patients with MTH + C, after multivariate analysis, was baseline renal insufficiency (OR = 8.2, 95% CI 1.8–47.1, and p = 0.009). Conclusion. Despite early cardiac catheterization, renal insufficiency and the absence of immediate CPR are potent predictors of death and poor neurologic outcome in patients with OHCA.
dc.description.versionPeer Reviewed
dc.identifier.citationAnjala Chelvanathan, David Allen, Hilary Bews, et al., “Renal Insufficiency and Early Bystander CPR Predict In-Hospital Outcomes in Cardiac Arrest Patients Undergoing Mild Therapeutic Hypothermia and Cardiac Catheterization: Return of Spontaneous Circulation, Cooling, and Catheterization Registry (ROSCCC Registry),” Cardiology Research and Practice, vol. 2016, Article ID 8798261, 7 pages, 2016. doi:10.1155/2016/8798261
dc.identifier.urihttp://dx.doi.org/10.1155/2016/8798261
dc.identifier.urihttp://hdl.handle.net/1993/31294
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2016 Anjala Chelvanathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleRenal Insufficiency and Early Bystander CPR Predict In-Hospital Outcomes in Cardiac Arrest Patients Undergoing Mild Therapeutic Hypothermia and Cardiac Catheterization: Return of Spontaneous Circulation, Cooling, and Catheterization Registry (ROSCCC Registry)
dc.typeJournal Article
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