A layer of hydrogel on PET dressings for low wound adherence and as a reservoir for new dendrimer based biocides for burn wound infection control
| dc.contributor.author | Asghari, Sogol | |
| dc.contributor.examiningcommittee | Logsetty,Sarvesh (Surgery) Gu, Xiaochen (College of Pharmacy) | en_US |
| dc.contributor.supervisor | Liu, Song (Biosystems Engineering) | en_US |
| dc.date.accessioned | 2015-12-23T14:40:30Z | |
| dc.date.available | 2015-12-23T14:40:30Z | |
| dc.date.issued | 2015 | |
| dc.degree.discipline | Biosystems Engineering | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Bacterial infection in burn wounds can jeopardize healing and can even lead to a patient’s death. Recently using a topical wound dressing with antimicrobial ability has been increasing. An ideal dressing for a burn wound is required to be antimicrobial, pain free and able to control the wound moisture to facilitate healing. In this research, a UV-radiation grafting method for depositing polyacrylamide (PAM) layer was used to improve the non-adherence properties of two commercially available silver based wound dressings. The dressing adherence, evaluated via an in vitro gelatine model, dramatically decreases after the deposition of PAM. This deposition did not negatively affect the antibacterial ability and cytotoxicity of the dressings. Furthermore, a poly(amidoamine) dendrimer based biocide was incorporated into PET dressings coated with poly(acrylic acid-co-acrylamide ) hydrogel. The resulting dressing was able to release a therapeutic dose of the antimicrobial agent in a sustained manner. | en_US |
| dc.description.note | February 2016 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/30985 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Low wound adherence | en_US |
| dc.subject | Silver dressing | en_US |
| dc.subject | Hydrogel | en_US |
| dc.subject | Acrylamide | en_US |
| dc.subject | Wound infection control | en_US |
| dc.subject | Dendrimer based biocide | en_US |
| dc.title | A layer of hydrogel on PET dressings for low wound adherence and as a reservoir for new dendrimer based biocides for burn wound infection control | en_US |
| dc.type | master thesis | en_US |