Sex-specific association of human milk hormones and asthma in the CHILD cohort

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dc.contributor.authorChan, Deborah
dc.contributor.authorBecker, Allan B
dc.contributor.authorMoraes, Theo J.
dc.contributor.authorMandhane, Piushkumar J
dc.contributor.authorSears, Malcolm
dc.contributor.authorTurvey, Stuart
dc.contributor.authorSubbarao, Padmaja
dc.contributor.authorField, Catherine
dc.contributor.authorAzad, Meghan
dc.date.accessioned2022-06-06T16:23:03Z
dc.date.available2022-06-06T16:23:03Z
dc.date.issued2020-01-18
dc.date.submitted2022-05-15T17:01:19Zen_US
dc.description.abstractAsthma is one of the most common chronic childhood diseases, affecting 15%-20% of children worldwide. The Developmental Origins of Health and Diseases hypothesis suggests that early childhood offers a critical opportunity to alter the development of chronic disease. During this period, breastfeeding is increasingly recognized as serving a dual role of both nutrition and immune protection. In the CHILD Cohort Study, we have observed a dose-dependent protective association between breastfeeding and possible or probable asthma at 3 years of age, suggesting a potential role for immunomodulatory components of human milk. In addition to transferring maternal antibodies and cytokines, human milk contains adipokines and metabolic hormones including adiponectin, leptin, and insulin. While these hormones are most often studied in relation to growth, appetite, and satiety, they also have immunomodulatory properties; yet, to our knowledge, they have never been studied in relation to asthma. It is well established that asthma affects more boys than girls in early childhood,1 but this sex difference is not fully understood. An emerging body of evidence suggests that human milk composition may differ when produced for sons vs. daughters. However, this has not been widely studied, and even less is known about the potentially sex-specific effects of human milk components on clinical outcomes such as asthma. Here, using data from the Canadian CHILD Cohort Study, we performed a sex-stratified analysis of human milk adiponectin, leptin, and insulin concentrations and their association with possible or probable asthma development by 3 years of age.en_US
dc.description.sponsorshipChildren's Hospital Research Institute of Manitoba Canadian Institutes of Health Research The Allergy, Genes and Environment Networks of Centres of Excellence of Canada Canada Research Chairs Programen_US
dc.identifier.doi10.1111/pai.13219
dc.identifier.urihttp://hdl.handle.net/1993/36537
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsopen accessen_US
dc.subjectAsthmaen_US
dc.subjectCHILD Cohort Studyen_US
dc.subjectHuman milk hormonesen_US
dc.titleSex-specific association of human milk hormones and asthma in the CHILD cohorten_US
dc.typeresearch articleen_US
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Pediatrics and Child Healthen_US
oaire.citation.endPage573en_US
oaire.citation.issue5en_US
oaire.citation.startPage570en_US
oaire.citation.titlePediatric Allergy and Immunologyen_US
oaire.citation.volume31en_US
project.funder.identifierhttp://dx.doi.org/10.13039/100008795en_US
project.funder.nameManitoba Medical Service Foundationen_US
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