Time spent above optimal cerebral perfusion pressure is not associated with failure to improve in outcome in traumatic brain injury
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Date
2023-12-14
Authors
Stein, Kevin
Froese, Logan
Gomez, Alwyn
Sainbhi, Amanjyot S.
Vakitbilir, Nuray
Ibrahim, Younis
Islam, Abrar
Marquez, Izabella
Amenta, Fiorella
Bergmann, Tobias
Journal Title
Journal ISSN
Volume Title
Publisher
SpringerOpen
Abstract
Background
Optimal cerebral perfusion pressure (CPPopt) has emerged as a promising personalized medicine approach to the management of moderate-to-severe traumatic brain injury (TBI). Though literature demonstrating its association with poor outcomes exists, there is yet to be work done on its association with outcome transition due to a lack of serial outcome data analysis. In this study we investigate the association between various metrics of CPPopt and failure to improve in outcome over time.
Methods
CPPopt was derived using three different cerebrovascular reactivity indices; the pressure reactivity index (PRx), the pulse amplitude index (PAx), and the RAC index. For each index, % times spent with cerebral perfusion pressure (CPP) above and below its CPPopt and upper and lower limits of reactivity were calculated. Patients were dichotomized based on improvement in Glasgow Outcome Scale-Extended (GOSE) scores into Improved vs. Not Improved between 1 and 3 months, 3 and 6 months, and 1- and 6-month post-TBI. Logistic regression analyses were then conducted, adjusting for the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) variables.
Results
This study included a total of 103 patients from the Winnipeg Acute TBI Database. Through Mann–Whitney U testing and logistic regression analysis, it was found that % time spent with CPP below CPPopt was associated with failure to improve in outcome, while % time spent with CPP above CPPopt was generally associated with improvement in outcome.
Conclusions
Our study supports the existing narrative that time spent with CPP below CPPopt results in poorer outcomes. However, it also suggests that time spent above CPPopt may not be associated with worse outcomes and is possibly even associated with improvement in outcome.
Description
Keywords
Optimal cerebral perfusion pressure, Outcome transition, Traumatic brain injury, Prediction, Treatment failure
Citation
Intensive Care Medicine Experimental. 2023 Dec 14;11(1):92