Pharmacoepidemiology and drug utilization of benzodiazepines and z-drugs among adults in Manitoba, Canada

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Brandt, Jaden
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Background: The use of benzodiazepines and z-drugs remains controversial given their potential for misuse and harm. Investigation of their use in Manitoba remains important for monitoring and improving prescribing patterns. Methods: Administrative data was used to conduct i) drug utilization study from 2001-2016, and ii) incident-user cohort study of patients with anxiety/insomnia. Results: i) Z-drug use increased on all measures while only dose intensity increased for benzodiazepines. Higher utilization occurred among females and those ≥65 years. ii) The proportion of patients who became long-term users (>6months) in their first episode of use ranged from 4.5-9.6%. Males, older age, socioeconomically deprived, use of opioids or psychotropic agents, and poor physical health, were associated with long-term use. Conclusion: While less than one in 10 were considered a long-term user of these agents, further investigation into whether specific factors associated with long-term use requires consideration during the prescribing of these agents is warranted.
Benzodiazepines, Epidemiology, Anxiety, Insomnia, Drug utilization
Drugs R D 17(4) 493-507
Clinical Drug Investigation 38(7) 565-572
Journal of Population Therapeutics and Clinical Pharmacology 26(1) 1-17