Vascular plaque detection from optical coherence tomography images

dc.contributor.authorPrakah, Ammu
dc.contributor.examiningcommitteeYahampath, Pradeepa (Electrical and Computer Engineering) Paliwal, Jitendra (Biosystems Engineering) Sarunic, Marinko V. (School of Engineering Science, Simon Fraser University)en_US
dc.contributor.supervisorSherif, Sherif S. (Electrical and Computer Engineering)en_US
dc.date.accessioned2021-04-28T17:56:38Z
dc.date.available2021-04-28T17:56:38Z
dc.date.copyright2021-03-09
dc.date.issued2021-03en_US
dc.date.submitted2021-03-09T18:29:46Zen_US
dc.degree.disciplineElectrical and Computer Engineeringen_US
dc.degree.levelDoctor of Philosophy (Ph.D.)en_US
dc.description.abstractIt is difficult to detect atherosclerotic plaque from optical coherence tomography (OCT) images via visual inspection. In this work, we developed three algorithms to allow us to detect atherosclerotic plaque more effectively: (i) a statistical method that uses higher-order moments; (ii) a model-based method that enables vascular plaque to be automatically identified based on the textural features in OCT images; (iii) and a sparsity-based segmentation algorithm in the curvelet domain. All three algorithms do not rely on visual inspection at all. The statistical method consists of three main components: extracting statistical image textural features using the Spatial Gray Level Dependence Matrix (SGLDM) method; applying an unsupervised Fuzzy C-means clustering algorithm to these features; and, finally, mapping specific clustered regions—namely, background, plaque, vascular tissue, and the deep-depth degraded signal in feature-space—back to the actual image. Since the use of the full set of 26 textural features is computationally expensive and may not be practical for real-time implementation, we identified a reduced set of 6 textural features, which were used to characterize vascular plaque via sparse principal component analysis. However, our clustering-based algorithm results had some limitations, most notably non-smooth and coarse segmentation results. To overcome this low spatial resolution limitation, we developed a stochastic model to segment OCT images of vascular tissue into plaque and non-plaque (i.e., healthy tissue) regions, as well as background regions. Our stochastic model is based on a maximum a posteriori-Markov Random Field (MRF-MAP) framework wherein OCT images of vascular tissue were modeled as a Markov random field. This MRF-MAP-based algorithm yielded results with better spatial resolution, but it is not consistent and also computationally expensive, thereby impractical for real-time implementation. Our third approach, using a sparsity-based segmentation algorithm in the curvelet domain, overcame the two limitations above by generating both fast and high-resolution vascular plaque detection from OCT images. We verified the validity of the results of all three methods using both qualitative and quantitative methods. Specifically, all results were compared with 1) actual photographic images of vascular tissue samples, 2) histology results, and 3) ground truth obtained from manual segmentations performed by four cardiovascular surgeons from the Intervention Cardiology Group at St. Boniface Hospital, Winnipeg, Manitoba. These comparisons of results demonstrated that our three methods allow good plaque detection, thus making them potential clinical tools for the detection of vascular plaque from OCT images and for clinical studies involving OCT imaging of vascular plaque. .en_US
dc.description.noteMay 2021en_US
dc.identifier.urihttp://hdl.handle.net/1993/35460
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectOptical Coherence Tomography, Vascular plaque, Image processing, Segmentation, Sparseen_US
dc.titleVascular plaque detection from optical coherence tomography imagesen_US
dc.typedoctoral thesisen_US
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