Diabetes in pregnancy and lung health in offspring: developmental origins of respiratory disease

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dc.contributor.authorAzad, Meghan
dc.contributor.authorMoyce, Brittany L
dc.contributor.authorGuillemette, Laetitia
dc.contributor.authorPascoe, Christopher
dc.contributor.authorWicklow, Brandy
dc.contributor.authorMcGavock, Jonathan
dc.contributor.authorHalayko, Andrew John
dc.contributor.authorDolinsky, Vernon Wayne
dc.date.accessioned2022-08-18T15:18:43Z
dc.date.available2022-08-18T15:18:43Z
dc.date.issued2017-01
dc.date.submitted2022-08-18T15:10:32Zen_US
dc.description.abstractDiabetes is an increasingly common complication of pregnancy. In parallel with this trend, a rise in chronic lung disease in children has been observed in recent decades. While several adverse health outcomes associated with exposure to diabetes in utero have been documented in epidemiological and experimental studies, few have examined the impact of diabetes in pregnancy on offspring lung health and respiratory disease. We provide a comprehensive overview of current literature on this topic, finding suggestive evidence that exposure to diabetes in utero may have adverse effects on lung development. Delayed lung maturation and increased risk of respiratory distress syndrome have been consistently observed among infants born to mothers with diabetes and these findings are also observed in some rodent models of diabetes in pregnancy. Further research is needed to confirm and characterize epidemiologic observations that diabetes in pregnancy may predispose offspring to childhood wheezing illness and asthma. Parallel translational studies in human pregnancy cohorts and experimental models are needed to explore the role of fetal programming and other potential biological mechanisms in this context.en_US
dc.description.sponsorshipThe Developmental Origins of Chronic Diseases in Children Network (DEVOTION) is supported by Research Manitoba and the Lawson Foundation. MBA and AJH are members of the Canadian Respiratory Research Network and the AllerGen Network of Centres of Excellence. BLM is the recipient of a Research Manitoba studentship.en_US
dc.identifier.doi10.1016/j.prrv.2016.08.007
dc.identifier.urihttp://hdl.handle.net/1993/36707
dc.language.isoengen_US
dc.publisherPaediatric Respiratory Reviewsen_US
dc.rightsopen accessen_US
dc.subjectMaternal Diabetesen_US
dc.subjectAsthmaen_US
dc.subjectLung developmenten_US
dc.subjectGestational Diabetesen_US
dc.titleDiabetes in pregnancy and lung health in offspring: developmental origins of respiratory diseaseen_US
dc.typepreprinten_US
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Pediatrics and Child Healthen_US
oaire.citation.endPage26en_US
oaire.citation.startPage19en_US
oaire.citation.titlePaediatric Respiratory Reviewsen_US
oaire.citation.volume21en_US
project.funder.identifierhttp://dx.doi.org/10.13039/100008794en_US
project.funder.nameResearch Manitobaen_US
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