Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery

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dc.contributor.authorHe, Wei
dc.contributor.authorGu, Xiaochen
dc.contributor.authorLiu, Song
dc.date.accessioned2018-10-09T15:14:41Z
dc.date.available2018-10-09T15:14:41Z
dc.date.issued2012-03-08
dc.date.submitted2018-10-05T21:23:09Zen
dc.description.abstractSurface functionalized polyurea microcapsules (MCQ) are synthesized in one step. Dimethyl-dodecyl-(5-hydroxy-pentyl)-ammonium bromide (DAB), a hydroxyl-end-capped quaternary ammonium salt, is synthesized and adopted as a new surfmer for the synthesis of MCQ. It is confirmed by fluorescein adsorption that DAB is covalently bonded to MCQ. The so-formed MCQ possess dual-functionality: contact infection control and sustained drug delivery. Agar diffusion antimicrobial tests confirm successful inhibition of multidrug- resistant E. coli by MCQ alone instead of by leaching of free quaternary ammonium salts. Furthermore, few E. coli colonies survive on an agar plate coated with 3–4 layers of MCQ. Dissolution tests show a typical first-order release profile of courmarin-1, a model dye, from MCQ.en_US
dc.description.sponsorshipthe Manitoba Health Research Council Operating, and Establishment Grants the Dr. Paul H.T. Thorlakson Foundation the University of Manitoba Research Grant Program.en_US
dc.identifier.citationHe, W.; Gu, X.; Liu, S.* Surfactant-free One-Step Synthesis of Dual-functional Polyurea Microcapsule: Contact Infection Control and Drug Delivery. Advanced Functional Materials, 2012; 22(19): 4023-31.en_US
dc.identifier.doi10.1002/adfm.201200656
dc.identifier.urihttp://hdl.handle.net/1993/33529
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsopen accessen_US
dc.subjectPolyurea Microcapsulesen_US
dc.subjectSurfactant-Free One-Step Synthesis of Microcapsulesen_US
dc.subjectDual-Functional Microcapsulesen_US
dc.subjectinfection controlen_US
dc.titleSurfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Deliveryen_US
dc.typeArticleen_US
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