Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery
Loading...
Date
2012-03-08
Authors
He, Wei
Gu, Xiaochen
Liu, Song
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Surface functionalized polyurea microcapsules (MCQ) are synthesized in
one step. Dimethyl-dodecyl-(5-hydroxy-pentyl)-ammonium bromide (DAB), a
hydroxyl-end-capped quaternary ammonium salt, is synthesized and adopted
as a new surfmer for the synthesis of MCQ. It is confirmed by fluorescein
adsorption that DAB is covalently bonded to MCQ. The so-formed MCQ possess
dual-functionality: contact infection control and sustained drug delivery.
Agar diffusion antimicrobial tests confirm successful inhibition of multidrug-
resistant E. coli by MCQ alone instead of by leaching of free quaternary
ammonium salts. Furthermore, few E. coli colonies survive on an agar plate
coated with 3–4 layers of MCQ. Dissolution tests show a typical first-order
release profile of courmarin-1, a model dye, from MCQ.
Description
Keywords
Polyurea Microcapsules, Surfactant-Free One-Step Synthesis of Microcapsules, Dual-Functional Microcapsules, infection control
Citation
He, W.; Gu, X.; Liu, S.* Surfactant-free One-Step Synthesis of Dual-functional Polyurea Microcapsule: Contact Infection Control and Drug Delivery. Advanced Functional Materials, 2012; 22(19): 4023-31.