pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery

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dc.contributor.authorSedigheh, Nazaripour
dc.contributor.examiningcommitteeJoe O'Neil (Chemistry) Emmanuel A. Ho (Pharmacy)en_US
dc.contributor.supervisorSong Liu (Biosystem Engineering)en_US
dc.date.accessioned2016-09-20T17:10:50Z
dc.date.available2016-09-20T17:10:50Z
dc.date.issued2016
dc.degree.disciplineChemistryen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractA new pH sensitive polyurethane intravaginal ring reservoir (PU Res IVR) drug delivery system was developed using a novel and versatile method. A combination of surface-initiated activator regenerated by electron transfer atom transfer radical polymerization (SI-ARGET-ATRP) and alkyne-azide click reaction was applied to graft pH sensitive polymers with different functional groups from the surface of PU Res IVR segments. Release studies showed that the dominant mechanism is " the through pore mechanism" in this system.en_US
dc.description.noteOctober 2016en_US
dc.identifier.urihttp://hdl.handle.net/1993/31828
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectpH Responsive, Polymer Brushes, Intravagianl Ring, Stimuli-Responsive,en_US
dc.titlepH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug deliveryen_US
dc.typemaster thesisen_US
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