pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery
dc.contributor.author | Sedigheh, Nazaripour | |
dc.contributor.examiningcommittee | Joe O'Neil (Chemistry) Emmanuel A. Ho (Pharmacy) | en_US |
dc.contributor.supervisor | Song Liu (Biosystem Engineering) | en_US |
dc.date.accessioned | 2016-09-20T17:10:50Z | |
dc.date.available | 2016-09-20T17:10:50Z | |
dc.date.issued | 2016 | |
dc.degree.discipline | Chemistry | en_US |
dc.degree.level | Master of Science (M.Sc.) | en_US |
dc.description.abstract | A new pH sensitive polyurethane intravaginal ring reservoir (PU Res IVR) drug delivery system was developed using a novel and versatile method. A combination of surface-initiated activator regenerated by electron transfer atom transfer radical polymerization (SI-ARGET-ATRP) and alkyne-azide click reaction was applied to graft pH sensitive polymers with different functional groups from the surface of PU Res IVR segments. Release studies showed that the dominant mechanism is " the through pore mechanism" in this system. | en_US |
dc.description.note | October 2016 | en_US |
dc.identifier.uri | http://hdl.handle.net/1993/31828 | |
dc.language.iso | eng | en_US |
dc.rights | open access | en_US |
dc.subject | pH Responsive, Polymer Brushes, Intravagianl Ring, Stimuli-Responsive, | en_US |
dc.title | pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery | en_US |
dc.type | master thesis | en_US |