pH Responsive Polymer Brushes grafted from the surface of Intravaginal Ring for on-demand drug delivery
Date
2016
Authors
Sedigheh, Nazaripour
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Abstract
A new pH sensitive polyurethane intravaginal ring reservoir (PU Res IVR) drug delivery system was developed using a novel and versatile method. A combination of surface-initiated activator regenerated by electron transfer atom transfer radical polymerization (SI-ARGET-ATRP) and alkyne-azide click reaction was applied to graft pH sensitive polymers with different functional groups from the surface of PU Res IVR segments. Release studies showed that the dominant mechanism is " the through pore mechanism" in this system.
Description
Keywords
pH Responsive, Polymer Brushes, Intravagianl Ring, Stimuli-Responsive,