The Role of the Insulin-Like Growth Factors and Their Binding Proteins in Glucose Homeostasis

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dc.contributor.authorMurphy, Liam J.
dc.date.accessioned2014-08-14T07:06:54Z
dc.date.available2014-08-14T07:06:54Z
dc.date.issued2003-1-1
dc.date.updated2014-08-14T07:06:54Z
dc.description.abstractThe insulin like growth factors (IGF-I and -II) are structurally and functionally related to insulin. While insulin is a key regulator of glucose homeostasis over the short term, emerging evidence suggests that the IGFs are involved in the longer term glucose homeostasis, possibly by modulating insulin sensitivity. Unlike insulin, the IGFs are present in most biological fluids as complexes with high affinity binding proteins, the insulin-like growth factor binding proteins (IGFBPs). The IGFBPs regulate the bioavailability of the IGFs. Of the six IGFBPs identified there is evidence from studies in transgenic mice that both IGFBP-1 and IGFBP-3 may have a role in glucose regulation.
dc.description.versionPeer Reviewed
dc.identifier.citationLiam J. Murphy, “The Role of the Insulin-Like Growth Factors and Their Binding Proteins in Glucose Homeostasis,” Experimental Diabesity Research, vol. 4, no. 4, pp. 213-224, 2003. doi:10.1155/EDR.2003.213
dc.identifier.doihttp://dx.doi.org/10.1155/EDR.2003.213
dc.identifier.urihttp://hdl.handle.net/1993/23787
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleThe Role of the Insulin-Like Growth Factors and Their Binding Proteins in Glucose Homeostasis
dc.typeJournal Article
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