Emerging Roles of Branched-Chain Amino Acid Supplementation in Human Diseases

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dc.contributor.authorTamanna, Nahid
dc.contributor.authorMahmood, Niaz
dc.date.accessioned2015-05-14T16:03:56Z
dc.date.available2015-05-14T16:03:56Z
dc.date.issued2014-11-12
dc.date.updated2015-03-29T13:25:27Z
dc.description.abstractThe branched-chain amino acids (BCAAs), namely, valine, leucine, and isoleucine, are indispensable amino acids required for body protein synthesis. Unlike other amino acids, the BCAAs are primarily catabolised in the extrahepatic tissues. The BCAAs play role in regulation of protein synthesis and turnover as well as maintenance of the body glutamate-glutamine level. In strenuous and traumatic conditions, the BCAAs are oxidized which limits their availability in tissues. Such condition affects the body glutamate-glutamine pool and protein synthesis mechanisms. Thus BCCA supplementation is emerging as a nutritional strategy for treating many diseases. Many studies have found that BCAA administration is able to improve the health status of the patients suffering from different diseases even though there are conditions where they do not exert any effect. There are also some reports where elevated BCAAs have been shown to be associated with the pathogenesis of diseases. In this review, we have discussed the implication of BCAA supplementation in different pathological conditions and their relevant outcomes.
dc.description.versionPeer Reviewed
dc.identifier.citationNahid Tamanna and Niaz Mahmood, “Emerging Roles of Branched-Chain Amino Acid Supplementation in Human Diseases,” International Scholarly Research Notices, vol. 2014, Article ID 235619, 8 pages, 2014. doi:10.1155/2014/235619
dc.identifier.urihttp://dx.doi.org/10.1155/2014/235619
dc.identifier.urihttp://hdl.handle.net/1993/30466
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2014 Nahid Tamanna and Niaz Mahmood. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleEmerging Roles of Branched-Chain Amino Acid Supplementation in Human Diseases
dc.typeJournal Article
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