Increased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injury

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dc.contributor.authorDyck, Allison
dc.contributor.examiningcommitteeMarotta, Jonathan (Psychology)en_US
dc.contributor.examiningcommitteeGlazebrook, Cheryl (Kinesiology and Recreation Management)en_US
dc.contributor.supervisorIvanco, Tammy (Psychology)en_US
dc.date.accessioned2018-09-13T20:42:40Z
dc.date.available2018-09-13T20:42:40Z
dc.date.issued2018-08-30en_US
dc.date.submitted2018-08-30T18:06:14Zen
dc.degree.disciplinePsychologyen_US
dc.degree.levelMaster of Arts (M.A.)en_US
dc.description.abstractBrain injury induces brain change, which is modulated by sex and developmental age. We examined brain change in juvenile rats after repeated mild brain traumatic injuries. We hypothesized the rat pups would show graded deficits in behavioural performance and a graded increase in protein expression, both increasing with the number of impacts. Three-week-old rats received 1-3 concussions over three days, compared to sham controls without concussive impact. The wire-hanging task revealed a dose-like effect of injury, with performance worsening with the addition of each injury. Glial acidic protein level was highest in the two-injury group. Corticosterone was significantly different for sex and injury status, without an interaction. Our findings suggest repetitive concussion causes rapid changes in motor behaviour and the brain in juvenile rats. Even mild brain injuries require care and attention to avoid repeated injuries and an increase to long-lasting brain disruption.en_US
dc.description.noteOctober 2018en_US
dc.identifier.urihttp://hdl.handle.net/1993/33356
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectPlasticityen_US
dc.subjectraten_US
dc.subjectjuvenileen_US
dc.subjectmTBIen_US
dc.subjectconcussionen_US
dc.subjectInflammationen_US
dc.subjectGFAPen_US
dc.subjectCORTen_US
dc.titleIncreased GFAP in motor cortex and bimanual coordination deficits in a rat (Rattus Norvegicus) model of repeated pediatric mild traumatic brain injuryen_US
dc.typemaster thesisen_US
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