Exploiting human adenovirus: constructing recombinant viral biotherapeutics and determining the function of the cellular protein ARGLU1

dc.contributor.authorBachus, Scott
dc.contributor.examiningcommitteeKumar, Ayush (Microbiology)en_US
dc.contributor.examiningcommitteeKindrachuk, Jason (Medical Microbiology and Infectious Diseases)en_US
dc.contributor.guestmembersCardona, Silvia (Microbiology)en_US
dc.contributor.supervisorPelka, Peter
dc.date.accessioned2022-08-24T21:05:50Z
dc.date.available2022-08-24T21:05:50Z
dc.date.copyright2022-08-24
dc.date.issued2022-08-23
dc.date.submitted2022-08-24T20:34:12Zen_US
dc.degree.disciplineMicrobiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractHuman adenovirus (HAdV) is a critical tool and essential model for studying virology, cell biology and molecular biology. Research into HAdV has led to a comprehensive understanding of the virus and its interaction with the host cell. These properties have been used to exploit HAdV to develop therapeutics and vaccines, and to understand the cell’s inner workings. This study first explores the use of HAdV as a molecular biology tool to develop and create a set of recombinant HAdV (rHAdV) to be used as potential vaccines or research reagents for the coronavirus disease 2019 (COVID-19) pandemic. Secondly, it utilizes the critical viral protein Early 1A (E1A) to identify the cellular E1A interaction hub protein, arginine and glutamate rich 1 (ARGLU1).en_US
dc.description.noteOctober 2022en_US
dc.identifier.urihttp://hdl.handle.net/1993/36756
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectAdV, HAdV, COVID-19, SARS-CoV-2, rHAdV, ARGLU1, cancer, transcriptional regulation, DNA Damage Response (DDR), anti-pause enhancersen_US
dc.titleExploiting human adenovirus: constructing recombinant viral biotherapeutics and determining the function of the cellular protein ARGLU1en_US
dc.typemaster thesisen_US
local.subject.manitobanoen_US
project.funder.identifierhttps://doi.org/10.13039/501100000038, https://doi.org/10.13039/501100000024, https://doi.org/10.13039/100010318en_US
project.funder.nameNatural Sciences and Engineering Research Council of Canada, Canadian Institutes of Health Research, University of Manitobaen_US
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