Effects of dietary n-3 and n-6 fatty acids and sex on the heart and brain oxylipin profiles in healthy rats

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dc.contributor.authorFerdouse, Afroza
dc.contributor.examiningcommitteeMoghadasian, Mohammed (Food and Human Nutritional Sciences) Mizuno, Tooru (Physiology)en_US
dc.contributor.supervisorAukema, Harold (Food and Human Nutritional Sciences)en_US
dc.date.accessioned2019-01-08T20:25:50Z
dc.date.available2019-01-08T20:25:50Z
dc.date.issued2019-01-02en_US
dc.date.submitted2019-01-03T18:05:20Zen
dc.degree.disciplineFood and Human Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractAlthough the effects of dietary polyunsaturated fatty acids (PUFA) are well-known in the heart and brain, little is known about oxylipins, their bioactive lipid metabolites. To provide fundamental data on these oxylipin profiles, and the effects of dietary PUFA and sex on these profiles, weanling female and male Sprague-Dawley rats were given diets modified in oil composition to provide higher levels of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid or linoleic acid, compared to control diets. Dietary PUFA mainly altered the levels of their own oxylipins, but also affected others. N-6 PUFA derived oxylipins were reduced by dietary n-3 PUFA in the heart, but not the brain, which generally was less resistant to diet-induced changes in oxylipins. Oxylipins were generally higher in females in heart but higher in males in brain. These data provide fundamental data that will inform studies on the roles of oxylipins in heart and brain.en_US
dc.description.noteFebruary 2019en_US
dc.identifier.urihttp://hdl.handle.net/1993/33665
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectOxylipinsen_US
dc.subjectEicosanoidsen_US
dc.subjectdietary faten_US
dc.subjectALAen_US
dc.subjectEPAen_US
dc.subjectDHAen_US
dc.subjectLAen_US
dc.subjectARAen_US
dc.subjectHearten_US
dc.subjectBrainen_US
dc.subjectSexen_US
dc.titleEffects of dietary n-3 and n-6 fatty acids and sex on the heart and brain oxylipin profiles in healthy ratsen_US
dc.typemaster thesisen_US
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