A role of Semaphorin-3E in regulating natural killer-cell migration in natural killer cell– dendritic cell crosstalk

dc.contributor.authorAlamri, Abdulaziz
dc.contributor.examiningcommitteeEllison, Cynthia (Immunology) Kauppinen, Tiina (Pharmacology and Therapeutics)en_US
dc.contributor.supervisorKung, Sam (Immunology) Gounni, Abdel Soussi (Immunology)en_US
dc.date.accessioned2016-07-27T18:41:10Z
dc.date.available2016-07-27T18:41:10Z
dc.date.issued2016
dc.degree.disciplineImmunologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractSemaphorin-3E (Sema-3E) is a member of the Semaphorin family that plays important regulatory roles in nervous and immune system. Natural Killer (NK) and dendritic cells (DC) are immune cell types that mediate/shape innate and adaptive immunity. The role of Sema-3E in regulating NK cell biology has not been reported. I first demonstrated that IL-2 activated NK cells expressed Sema-3E receptors on cell surface. I compared NK migratory responses towards conditioned media of DC (immature, LPS- or Poly I:C stimulated) derived from Sema-3E+/+ or Sema-3E-/- mice. Of interest, I observed that activated NK cells exhibited a two-fold increase in the migrations toward immature Sema-3E -/- DC conditioned medium when compared to that of the immature Sema-3E+/+ DC. My work revealed a novel role of Sema-3E in limiting NK-cell migrations toward immature DC in NK-DC crosstalk. Future delineations of the impact and signaling of the Sema-3E pathway in NK-DC crosstalk may support novel development of immunotherapy for cancer and infectious diseases.en_US
dc.description.noteOctober 2016en_US
dc.identifier.citationMLAen_US
dc.identifier.urihttp://hdl.handle.net/1993/31533
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectImmunologyen_US
dc.titleA role of Semaphorin-3E in regulating natural killer-cell migration in natural killer cell– dendritic cell crosstalken_US
dc.typemaster thesisen_US
local.subject.manitobayesen_US
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