A role of Semaphorin-3E in regulating natural killer-cell migration in natural killer cell– dendritic cell crosstalk
| dc.contributor.author | Alamri, Abdulaziz | |
| dc.contributor.examiningcommittee | Ellison, Cynthia (Immunology) Kauppinen, Tiina (Pharmacology and Therapeutics) | en_US |
| dc.contributor.supervisor | Kung, Sam (Immunology) Gounni, Abdel Soussi (Immunology) | en_US |
| dc.date.accessioned | 2016-07-27T18:41:10Z | |
| dc.date.available | 2016-07-27T18:41:10Z | |
| dc.date.issued | 2016 | |
| dc.degree.discipline | Immunology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Semaphorin-3E (Sema-3E) is a member of the Semaphorin family that plays important regulatory roles in nervous and immune system. Natural Killer (NK) and dendritic cells (DC) are immune cell types that mediate/shape innate and adaptive immunity. The role of Sema-3E in regulating NK cell biology has not been reported. I first demonstrated that IL-2 activated NK cells expressed Sema-3E receptors on cell surface. I compared NK migratory responses towards conditioned media of DC (immature, LPS- or Poly I:C stimulated) derived from Sema-3E+/+ or Sema-3E-/- mice. Of interest, I observed that activated NK cells exhibited a two-fold increase in the migrations toward immature Sema-3E -/- DC conditioned medium when compared to that of the immature Sema-3E+/+ DC. My work revealed a novel role of Sema-3E in limiting NK-cell migrations toward immature DC in NK-DC crosstalk. Future delineations of the impact and signaling of the Sema-3E pathway in NK-DC crosstalk may support novel development of immunotherapy for cancer and infectious diseases. | en_US |
| dc.description.note | October 2016 | en_US |
| dc.identifier.citation | MLA | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/31533 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Immunology | en_US |
| dc.title | A role of Semaphorin-3E in regulating natural killer-cell migration in natural killer cell– dendritic cell crosstalk | en_US |
| dc.type | master thesis | en_US |
| local.subject.manitoba | yes | en_US |