ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females

Simple item page
dc.contributor.authorGabbs, Melissa
dc.contributor.examiningcommitteeZahradka, Peter (Human Nutritional Sciences/Physiology and Pathophysiology) Ravandi, Amir (Cardiology and Physiology)en_US
dc.contributor.supervisorAukema, Harold (Human Nutritional Sciences)en_US
dc.date.accessioned2017-02-16T16:55:13Z
dc.date.available2017-02-16T16:55:13Z
dc.date.issued2015-09en_US
dc.degree.disciplineHuman Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractTime course changes in oxylipin profiles among healthy, young individuals consuming high doses of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) remain to be determined. Differences in lipid metabolism suggest the importance of separating sexes when investigating the effect of omega-3 supplementation on the oxylipin profile. Individuals (n=12) participated in a double-blind randomized cross-over trial where ALA oil (4g/day ALA) and DHA oil (4g/day DHA) were consumed for four weeks. Oxylipins from plasma, serum, and supplemental oils were analyzed. Females responded more immediately than males to DHA oil treatment and had higher levels of several DHA derived oxylipins, while ALA oil had a minimal effect on oxylipin production. Several oxylipins were elevated in serum when compared to plasma. Further, oxylipins were present in both supplemental oils. These results can be used to further explore oxylipin profiles in males and females and to help explain the impact of omega-3 supplementation.en_US
dc.description.noteFebruary 2017en_US
dc.identifier.citationGabbs, M., et al., Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. Adv Nutr, 2015. 6(5): p. 513-40.en_US
dc.identifier.urihttp://hdl.handle.net/1993/32141
dc.language.isoengen_US
dc.publisherAdvances in Nutritionen_US
dc.rightsopen accessen_US
dc.subjectOxylipinen_US
dc.subjectDocosahexaenoic aciden_US
dc.subjectAlpha-linolenic aciden_US
dc.subjectOmega-3en_US
dc.titleALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and femalesen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gabbs_Melissa.pdf
Size:
7.06 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.2 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica