ALA and DHA rich oils alter blood oxylipin profiles differently in young healthy males and females

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Gabbs, Melissa
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Advances in Nutrition
Time course changes in oxylipin profiles among healthy, young individuals consuming high doses of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) remain to be determined. Differences in lipid metabolism suggest the importance of separating sexes when investigating the effect of omega-3 supplementation on the oxylipin profile. Individuals (n=12) participated in a double-blind randomized cross-over trial where ALA oil (4g/day ALA) and DHA oil (4g/day DHA) were consumed for four weeks. Oxylipins from plasma, serum, and supplemental oils were analyzed. Females responded more immediately than males to DHA oil treatment and had higher levels of several DHA derived oxylipins, while ALA oil had a minimal effect on oxylipin production. Several oxylipins were elevated in serum when compared to plasma. Further, oxylipins were present in both supplemental oils. These results can be used to further explore oxylipin profiles in males and females and to help explain the impact of omega-3 supplementation.
Oxylipin, Docosahexaenoic acid, Alpha-linolenic acid, Omega-3
Gabbs, M., et al., Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. Adv Nutr, 2015. 6(5): p. 513-40.