A dressing solution for burn wounds: antibacterial and low-adherent wound dressings

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dc.contributor.authorPu, Tianyun
dc.contributor.examiningcommitteeHorne, Lena (Textile Sciences) Holley, Rick (Food Science)en_US
dc.contributor.supervisorLiu, Song (Textile Sciences)en_US
dc.date.accessioned2012-10-29T18:31:00Z
dc.date.available2012-10-29T18:31:00Z
dc.date.issued2012-07en_US
dc.degree.disciplineTextile Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractConsidering the infection and second trauma caused by dressing changes, development of antibacterial and low-adherent wound dressings is urgently needed. Silver ion is a widely used antimicrobial agent, but its cytotoxicity remains a problem. In this study, low-adherent PAM (polyacrylamide) hydrogel incorporated with less toxic AgNP (silver nanoparticle), was immobilized onto PET (poly(ethylene terephthalate)) substrates by an IPN (interpenetrating polymer network) method. The modified PET is effectively antibacterial and the surface is significantly less adherent than untreated PET. However, silver-resistant bacteria become a potential problem. Thus, ionic 5,5-dimethylhydantoin (DMH) analogues containing either a quaternary ammonium moiety or a phosphonate functional group were designed and synthesized. The DMH analogues were converted to antibacterial N-chloramine counterparts through chlorination to serve as potential alternatives to AgNP. The N-chloramine with a structural cation exhibited distinctly enhanced antibacterial functions both in solution and after immobilization on fabrics.en_US
dc.description.noteFebruary 2013en_US
dc.identifier.citationLi,L.; Pu, T.; Zhanel, G.; Zhao, N.; Ens, W.; Liu, S. New Biocide with Both N-Chloramine and Quaternary Ammonium Moieties Exerts Enhanced Bactericidal Activity. Advanced Healthcare Materials 2012, 1, 609-620.en_US
dc.identifier.urihttp://hdl.handle.net/1993/9815
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsopen accessen_US
dc.subjectdressingen_US
dc.subjectantibacterialen_US
dc.subjectlow-adherenten_US
dc.titleA dressing solution for burn wounds: antibacterial and low-adherent wound dressingsen_US
dc.typemaster thesisen_US
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