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    2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

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    Date
    2010-07-28
    Author
    Bowen, Tom
    Cicardi, Marco
    Farkas, Henriette
    Bork, Konrad
    Longhurst, Hilary J
    Zuraw, Bruce
    Aygoeren-Pursun, Emel
    Craig, Timothy
    Binkley, Karen
    Hebert, Jacques
    Ritchie, Bruce
    Bouillet, Laurence
    Betschel, Stephen
    Cogar, Della
    Dean, John
    Devaraj, Ramachand
    Hamed, Azza
    Kamra, Palinder
    Keith, Paul K
    Lacuesta, Gina
    Leith, Eric
    Lyons, Harriet
    Mace, Sean
    Mako, Barbara
    Neurath, Doris
    Poon, Man-Chiu
    Rivard, Georges-Etienne
    Schellenberg, Robert
    Rowan, Dereth
    Rowe, Anne
    Stark, Donald
    Sur, Smeeksha
    Tsai, Ellie
    Warrington, Richard
    Waserman, Susan
    Ameratunga, Rohan
    Bernstein, Jonathan
    Bjorkander, Janne
    Brosz, Kristylea
    Brosz, John
    Bygum, Anette
    Caballero, Teresa
    Frank, Mike
    Fust, George
    Harmat, George
    Kanani, Amin
    Kreuz, Wolfhart
    Levi, Marcel
    Li, Henry
    Martinez-Saguer, Inmaculada
    Moldovan, Dumitru
    Nagy, Istvan
    Nielsen, Erik W
    Nordenfelt, Patrik
    Reshef, Avner
    Rusicke, Eva
    Smith-Foltz, Sarah
    Spath, Peter
    Varga, Lilian
    Xiang, Zhi Y
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    Abstract
    Abstract Background We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Objective To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010). Methods The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review. Results This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference. Conclusions Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.
    URI
    http://hdl.handle.net/1993/8618
    DOI
    10.1186/1710-1492-6-24
    Collections
    • Rady Faculty of Health Sciences Scholarly Works [1296]
    • University of Manitoba Scholarship [1952]

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